Powder: -20°C for 3 years | In solvent: -80°C for 1 year
PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 195.00 | |
5 mg | In stock | $ 437.00 | |
10 mg | In stock | $ 646.00 | |
25 mg | In stock | $ 987.00 | |
50 mg | In stock | $ 1,380.00 | |
100 mg | In stock | $ 1,860.00 |
Description | PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis. |
Targets&IC50 | LOXL3:63 nM (human), LOXL2:<40 nM (across all mammalian species) |
In vitro | PXS-5153A is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases. PXS-5153A exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested. PXS-5153A also inhibits human LOXL3 with an IC50 value of 63 nM[1]. |
In vivo | rhLOXL2 dose-dependently induces oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl4 treated animals. Mature crosslink formation is also reduced by PXS-5153A treatment. All groups with therapeutic treatment of PXS-5153A show a significant reduction in DHLNL formation and HYP compared to the CCl4 treated animals[1]. |
Molecular Weight | 475.41 |
Formula | C20H25Cl2FN4O2S |
CAS No. | 2125956-82-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
H2O: 20mg/mL
DMSO: 20mg/mL
You can also refer to dose conversion for different animals. More
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PXS-5153A 2125956-82-1 Neuroscience Others Monoamine Oxidase MAO PXS 5153A PXS5153A inhibit Inhibitor inhibitor