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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $195 | In Stock | |
5 mg | $437 | In Stock | |
10 mg | $646 | In Stock | |
25 mg | $987 | In Stock | |
50 mg | $1,380 | In Stock | |
100 mg | $1,860 | In Stock |
Description | PXS-5153A is an effective, selective, and fast-acting inhibitor of lysyl oxidase like 2/3 enzymes with enzymatic activity almost entirely blocked within 15 minutes. PXS-5153A could reduce crosslinks and ameliorates fibrosis. |
In vitro | PXS-5153A is >40-fold selective for LOXL2 over both LOX and LOXL1 and >700-fold selective over other related amine oxidases. PXS-5153A exhibits an IC50 of <40 nM for LOXL2 across all mammalian species tested. PXS-5153A also inhibits human LOXL3 with an IC50 value of 63 nM[1]. |
In vivo | rhLOXL2 dose-dependently induces oxidation of collagen with PXS-5153A dose-dependently impeding collagen oxidation. Therapeutic treatment of PXS-5153A substantially reduces immature crosslink formation compared with the CCl4 treated animals. Mature crosslink formation is also reduced by PXS-5153A treatment. All groups with therapeutic treatment of PXS-5153A show a significant reduction in DHLNL formation and HYP compared to the CCl4 treated animals[1]. |
Molecular Weight | 475.41 |
Formula | C20H25Cl2FN4O2S |
Cas No. | 2125956-82-1 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | ||||||||||
Solubility Information | H2O: 20mg/mL DMSO: 45 mg/mL (94.66 mM) ![]() | ||||||||||
Solution Preparation Table | |||||||||||
DMSO
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