Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells.
Description | Physalin A exerts anti-tumor activity in non-small cell lung cancer cell lines by suppressing JAK/STAT3 signaling, it inhibits androgen-independent prostate cancer cell growth through activation of cell apoptosis and downregulation of androgen receptor expression. Physalin A induces apoptosis via p53-Noxa-mediated ROS generation, and autophagy plays a protective role against apoptosis through p38-NF-κB survival pathway in A375-S2 cells. |
Molecular Weight | 526.538 |
Formula | C28H30O10 |
CAS No. | 23027-91-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
( < 1 mg/ml refers to the product slightly soluble or insoluble )
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Physalin A 23027-91-0 JAK/STAT信号通路 MAPK信号通路 NF-Kb信号通路 表观遗传 凋亡 干细胞 免疫与炎症 内分泌与激素 血管生成 自噬 NF-κB JNK JAK Androgen Receptor Autophagy BCL ERK p38 MAPK p53 ROS STAT Inhibitor inhibitor inhibit