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Platycodin D

Catalog No. T3889   CAS 58479-68-8

Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.

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Platycodin D Chemical Structure
Platycodin D, CAS 58479-68-8
Pack Size Availability Price/USD Quantity
5 mg In stock $ 52.00
10 mg In stock $ 89.00
25 mg In stock $ 155.00
50 mg In stock $ 238.00
100 mg In stock $ 397.00
500 mg In stock $ 893.00
1 mL * 10 mM (in DMSO) In stock $ 58.00
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Purity: 99.79%
Purity: 99.43%
Purity: 99.2%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Platycodin D may stimulate TNF-α synthesis or inhibit degradation of TNF-α mRNA. Platycodin D (10/30 μM) suppresses prostaglandin E2 production in rat peritoneal macrophages stimulated by the protein kinase C activator 12-O-tetradecanoyl phorbol 13-acetate (TPA). Platycodin D and D3 are useful as expectorant agents in the treatment of various airway diseases, they can increase mucin release from rat and hamster tracheal surface epithelial cell culture and also from intact rat trachea upon nebulization.
Source
Molecular Weight 1225.32
Formula C57H92O28
CAS No. 58479-68-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 81.6 mM

TargetMolReferences and Literature

1. Kwon OG,ET AL. The Effects of Platycodin D, a Saponin Purified from Platycodi Radix, on Collagen-Induced DBA/1J Mouse Rheumatoid Arthritis. Evid Based Complement Alternat Med. 2014;22014:954508. 2. Chen T, et al. Protective effect of platycodin D on liver injury in alloxan-induced diabetic mice via regulation of Treg/Th17 balance. Int Immunopharmacol. 2015 Jun;26(2):338-48.

TargetMolCitations

1. Lee S J, Kim H W, Lee S, et al. Characterization of Saponins from Various Parts of Platycodon grandiflorum Using UPLC-QToF/MS. Molecules. 2022, 27(1): 107.

Related compound libraries

This product is contained In the following compound libraries:
GPCR Compound Library Anti-Aging Compound Library Epigenetics Compound Library Anti-Pancreatic Cancer Compound Library Neuronal Differentiation Compound Library Anti-Obesity Compound Library Antioxidant Compound Library Bioactive Compounds Library Max Immunology/Inflammation Compound Library Coagulation and Anticoagulation Compound Library

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Keywords

Platycodin D 58479-68-8 Chromatin/Epigenetic GPCR/G Protein Immunology/Inflammation PI3K/Akt/mTOR signaling AMPK Prostaglandin Receptor Inhibitor inhibit AMP-activated protein kinase inhibitor

 

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