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Potassium 1H-indol-3-yl sulfate

Catalog No. T4938   CAS 2642-37-7
Synonyms: Indoxyl sulfate potassium salt, Potassium 3-indoxyl sulfate

Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of immune-inflammatory conditions and potassium 1H-indol-3-yl sulfate has been shown to be a ligand for AhR. Potassium 1H-indol-3-yl sulfate is also a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, potassium 1H-indol-3-yl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. Potassium 1H-indol-3-yl sulfate at 250 μM can induce the activation of NF-Κb, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.

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Potassium 1H-indol-3-yl sulfate Chemical Structure
Potassium 1H-indol-3-yl sulfate, CAS 2642-37-7
Pack Size Availability Price/USD Quantity
5 mg In stock $ 34.00
10 mg In stock $ 54.00
25 mg In stock $ 90.00
50 mg In stock $ 139.00
100 mg In stock $ 228.00
200 mg In stock $ 343.00
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Purity: 100%
Purity: 99.87%
Purity: 99.87%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Potassium 1H-indol-3-yl sulfate (Potassium 3-indoxyl sulfate) is an agonist for the human Aryl Hydrocarbon Receptor (AhR). The Aryl Hydrocarbon Receptor (AhR) has recently emerged as a pathophysiological regulator of immune-inflammatory conditions and potassium 1H-indol-3-yl sulfate has been shown to be a ligand for AhR. Potassium 1H-indol-3-yl sulfate is also a metabolite of tryptophan derived from dietary protein. Tryptophan is metabolized by intestinal bacteria into indole, which is absorbed into the blood and then further metabolized to indoxyl sulfate in the liver, which is normally excreted in urine. In chronic kidney disease patients where renal function is compromised, potassium 1H-indol-3-yl sulfate can accumulate in serum as a uremic toxin, inducing oxidative stress and accelerating progression of the disease. Potassium 1H-indol-3-yl sulfate at 250 μM can induce the activation of NF-Κb, promoting the expression of both TGF-β1 and Smad3 expression in proximal tubular cells of rats, which is associated with profibrotic activity.
Synonyms Indoxyl sulfate potassium salt, Potassium 3-indoxyl sulfate
Molecular Weight 251.3
Formula C8H6KNO4S
CAS No. 2642-37-7

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 5.5 mg/mL (21.89 mM)

TargetMolReferences and Literature

1. Zgoda-Pols J R , Chowdhury S , Wirth M , et al. Metabolomics analysis reveals elevation of 3-indoxyl sulfate in plasma and brain during chemically-induced acute kidney injury in mice: Investigation of nicotinic acid receptor agonists[J]. Toxicology & Applied Pharmacology, 2011, 255(1):48-56. 2. Ito S , Osaka M , Edamatsu T , et al. Crucial Role of the Aryl Hydrocarbon Receptor (AhR) in Indoxyl Sulfate-Induced Vascular Inflammation.[J]. Journal of Atherosclerosis & Thrombosis, 2016, 23(8):iii510-iii511.

Related compound libraries

This product is contained In the following compound libraries:
Human Endogenous Metabolite Library Natural Product Library for HTS Gut Microbial Metabolite Library Ferroptosis Compound Library Immunology/Inflammation Compound Library NO PAINS Compound Library Natural Product Library HIF-1 Signaling Pathway Compound Library Human Metabolite Library Human Endogenous Metabolite Compound Library Plus

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Keywords

Potassium 1H-indol-3-yl sulfate 2642-37-7 Immunology/Inflammation Metabolism AhR Endogenous Metabolite Potassium 1H-indol-3-yl Sulfate Indoxyl sulfate potassium salt Potassium 1Hindol3yl sulfate Inhibitor Indoxyl sulfate potassium Potassium 3-indoxyl Sulfate inhibit Potassium 3-indoxyl sulfate Potassium 1H indol 3 yl sulfate inhibitor

 

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