Home Tools
Log in
Cart

QNZ

Catalog No. T6204   CAS 545380-34-5
Synonyms: CAY10470, EVP4593

QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
QNZ Chemical Structure
QNZ, CAS 545380-34-5
Pack Size Availability Price/USD Quantity
1 mg In stock $ 36.00
2 mg In stock $ 52.00
5 mg In stock $ 85.00
10 mg In stock $ 143.00
25 mg In stock $ 238.00
50 mg In stock $ 347.00
100 mg In stock $ 516.00
1 mL * 10 mM (in DMSO) In stock $ 94.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.17%
Purity: 98.16%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description QNZ (EVP4593) (EVP4593) is an effective inhibitor of NF-κB activation and TNF-α production. The IC50 of QNZ for NF-κB and TNF-α is11 nM and 7 nM, respectively.
Targets&IC50 TNF-α:7 nM
Synonyms CAY10470, EVP4593
Molecular Weight 356.42
Formula C22H20N4O
CAS No. 545380-34-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

H2O: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 5 mg/mL (14.02 mM)

TargetMolReferences and Literature

1. Tobe M, et al. Bioorg Med Chem, 2003, 11(3), 383-391. 2. VA Vigont, et al. Biochemistry (Mosc), 2012, 6(2), 206-214. 3. Armstrong SJ, et al. Neurosci Lett, 2008, 439(1), 42-46. 4. Li L, et al. J Cell Mol Med, 2009, 13(8B), 2684-2692. 5. Yang RH, et al. Mol Pain, 2009, 28(5), 26. 6. Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency[J]. Journal of Hazardous Materials. 2020: 124566. 7. Wu J, et al. Enhanced Store-Operated Calcium Entry Leads to Striatal Synaptic Loss in a Huntington's Disease Mouse Model. J Neurosci. 2016 Jan 6;36(1):125-41. 8. Hu, Qiuhui, Hengjun Du, Gaoxing Ma, Fei Pei, Ning Ma, Biao Yuan, Paul A. Nakata, and Wenjian Yang. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii [J]. Food Funct. 2018 Jul 17;9(7):3764-3775. 9. Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency[J]. Journal of Hazardous Materials. 2020: 124566.

TargetMolCitations

1. Lai X, Wang M, Zhu Y, et al. ZnO NPs delay the recovery of psoriasis-like skin lesions through promoting inflammation and keratinocyte apoptosis via nuclear translocation of phosphorylated NF-κB p65 and cysteine deficiency. Journal of Hazardous Materials. 2020: 124566 2. Hu Q, Du H, Ma G, et al. Purification, identification and functional characterization of an immunomodulatory protein from Pleurotus eryngii. Food & Function. 2018, 9(7): 3764-3775 3. Zhang R, Tang L, Wang Y, et al.A Dendrimer Peptide (KK2DP7) Delivery System with Dual Functions of Lymph Node Targeting and Immune Adjuvants as a General Strategy for Cancer Immunotherapy.Advanced Science.2023: 2300116.

Related compound libraries

This product is contained In the following compound libraries:
Pyroptosis Compound Library Anti-Diabetic Compound Library Oxidation-Reduction Compound Library Anti-Breast Cancer Compound Library Antidepressant Compound Library Anti-COVID-19 Compound Library Bioactive Compounds Library Max Bioactive Lipid Compound Library Anti-Aging Compound Library Angiogenesis related Compound Library

Related Products

Related compounds with same targets
Specnuezhenide Sodium salicylate ent-11alpha-Hydroxy-15-oxokaur-16-en-19-oic acid Sodium Houttuyfonate Anti-inflammatory agent 48 8-Deoxygartanin Taraxerol Gypenoside L

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

QNZ 545380-34-5 Apoptosis NF-Κb TNF NF-κB TNFR CAY-10470 EVP-4593 Inhibitor Nuclear factor-kappaB CAY10470 EVP 4593 inhibit Tumor Necrosis Factor Receptor Nuclear factor-κB CAY 10470 TNF Receptor EVP4593 inhibitor

 

TargetMol