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RG13022

Catalog No. T3545Cas No. 136831-48-6
Alias Tyrphostin RG13022, RG 13022

RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).

RG13022

RG13022

Purity: 98.38%
Catalog No. T3545Alias Tyrphostin RG13022, RG 13022Cas No. 136831-48-6
RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).
Pack SizePriceAvailabilityQuantity
2 mg$39In Stock
5 mg$55In Stock
10 mg$80In Stock
25 mg$189In Stock
50 mg$320In Stock
100 mg$506In Stock
1 mL x 10 mM (in DMSO)$58In Stock
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Purity:98.38%
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Product Introduction

Bioactivity
Description
RG13022 (Tyrphostin RG13022) is a tyrosine kinase inhibitor; inhibits the autophosphorylation reaction of the EGF receptor (IC50: 4 μM).
Targets&IC50
EGF:4 μM
In vitro
RG13022 suppresses EGF-stimulated cancer cell proliferation and inhibits EGF receptor autophosphorylation in immunoprecipitates (IC50: 4 μM) in a cell-free reaction. It inhibits colony formation (IC50: 1 μM) and DNA synthesis (IC50: 3 μM) in HER 14 cells stimulated by 50 ng/mL EGF, dose-dependently. Additionally, RG13022 inhibits growth stimulated by insulin, insulin-like growth factor I, insulin-like growth factor II, or transforming growth factor alpha. It completely blocks estrogen-stimulated phosphorylation of the EGF receptor and estrogen-induced cell proliferation, indicating that functioning TK pathways are essential for estrogen action.
In vivo
RG13022 suppresses tumor growth and extends the lifespan of tumor-bearing nude mice.
Cell Research
40 mM stock solutions of RG13022 is made in 100% DMSO and diluted with the culture medium before addition to the cells. MH-85 cells and HER 14 cells are plated in culture medium in the presence or absence of increasing concentrations of RG-13022 or RG-14620 for 10 days. At the end of culture, the cells are fixed with 4% (v/v) formaldehyde and stained with hematoxylin. Numbers of colonies including more than 20 cells in each well are counted under the microscope[1].
AliasTyrphostin RG13022, RG 13022
Chemical Properties
Molecular Weight266.29
FormulaC16H14N2O2
Cas No.136831-48-6
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 50 mg/mL (187.76 mM)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM3.7553 mL18.7765 mL37.5530 mL187.7652 mL
5 mM0.7511 mL3.7553 mL7.5106 mL37.5530 mL
10 mM0.3755 mL1.8777 mL3.7553 mL18.7765 mL
20 mM0.1878 mL0.9388 mL1.8777 mL9.3883 mL
50 mM0.0751 mL0.3755 mL0.7511 mL3.7553 mL
100 mM0.0376 mL0.1878 mL0.3755 mL1.8777 mL

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