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RR-11a analog

Catalog No. T12770 CAS 685543-66-2

Synonyms: aza-peptide Michael acceptor, 7a

RR-11a analog is an inhibitor of asparaginyl endopeptidase with IC50s of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively.

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RR-11a analog, CAS 685543-66-2

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	RR-11a analog is an inhibitor of asparaginyl endopeptidase with IC50s of 4.5 nM, 4.5 nM and 31 nM for AE1 in Trichomonas Vaginalis, AE in Ixodes ricinus and AE in Schistosoma mansoni, respectively.
Targets&IC50	AE in Ixodes ricinus:4.5 nM , AE1 in Trichomonas Vaginalis:4.5 nM , AE in Schistosoma mansoni:31 nM
In vivo	RR-11a analog shows a t1/2 of 3-10 min[2].

Synonyms	aza-peptide Michael acceptor, 7a
Molecular Weight	491.49
Formula	C22H29N5O8
CAS No.	685543-66-2

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 112.5mg/mL (228.9mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Götz MG, et al. Aza-peptidyl Michael acceptors. A new class of potent and selective inhibitors of asparaginyl endopeptidases (legumains) from evolutionarily diverse pathogens. J Med Chem. 2008 May 8;51(9):2816-32. 2. Ekici OD, et al. Aza-peptide Michael acceptors: a new class of inhibitors specific for caspases and other clan CD cysteine proteases. J Med Chem. 2004 Apr 8;47(8):1889-92.

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Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

RR-11a analog 685543-66-2 Microbiology/Virology Parasite aza-peptide Michael acceptor, 7a Inhibitor inhibitor inhibit

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