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Ro 90-7501

Catalog No. T16773 CAS 293762-45-5

Synonyms: RO-90-7501

Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.

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Ro 90-7501, CAS 293762-45-5

Pack Size	Availability	Price/USD
1 mg	In stock	$ 30.00
5 mg	In stock	$ 68.00
10 mg	In stock	$ 123.00
25 mg	In stock	$ 272.00
50 mg	In stock	$ 463.00
100 mg	In stock	$ 787.00

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Purity: 99.80%

Purity: 97.19%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Ro 90-7501 is an amyloid β42 (Aβ42) protofibrillar and TPR-dependent PP5 inhibitor, a novel radiosensitiser for cervical cancer cells, which inhibits ATM phosphorylation, promotes apoptosis, and induces cell-cycle arrest.Ro 90-7501 exhibits antiviral activity and potential anticancer activity by inhibiting ATM phosphorylation and DNA repair, and by inhibiting HCMV.
In vitro	Compared to control HeLa and ME-180 cells, Ro 90-7501 significantly enhances radiation sensitivity. Following irradiation, Ro 90-7501 markedly increases apoptosis and impairs the cell cycle. Post-irradiation, Ro 90-7501 suppresses the phosphorylation of ATM and its downstream proteins, such as H2AX, Chk1, and Chk2[2]. RO 90-7501 itself does not affect IFN-β and NFκB promoter activity but significantly enhances poly I:C-induced IFN-β promoter activation and dose-dependently inhibits NF-κB activation. Treatment with RO 90-7501 significantly enhances the antiviral activity of poly I:C[1].
In vivo	Treatment with Ro 90-7501 (5 μg/g; intraperitoneal injection; daily; continuous for 21 days; female BALB/c nude mice) significantly delays tumor growth and markedly reduces tumor volume[2].

Synonyms	RO-90-7501
Molecular Weight	340.38
Formula	C20H16N6
CAS No.	293762-45-5

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (88.14 mM), Sonication is recommended.

References and Literature

1. Guo F, et al. RO 90-7501 enhances TLR3 and RLR agonist induced antiviral response. PLoS One. 2012;7(10):e42583. 2. Tamari K, et al. Ro 90-7501 Is a Novel Radiosensitizer for Cervical Cancer Cells that Inhibits ATM Phosphorylation. Anticancer Res. 2019 Sep;39(9):4805-4810. 3. Hong TJ, et al. Ro 90-7501 inhibits PP5 through a novel, TPR-dependent mechanism. Biochem Biophys Res Commun. 2017 Jan 8;482(2):215-220. 4. Bohrmann B, et al. Self-assembly of beta-amyloid 42 is retarded by small molecular ligands at the stage of structural intermediates. J Struct Biol. 2000 Jun;130(2-3):232-46.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Kinase Inhibitor Library Anti-Neurodegenerative Disease Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Ro 90-7501 293762-45-5 Apoptosis DNA Damage/DNA Repair Metabolism Neuroscience PI3K/Akt/mTOR signaling Proteases/Proteasome Stem Cells ATM/ATR Phosphatase Gamma-secretase RO-90-7501 Ro 907501 Ro 90 7501 inhibitor inhibit

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