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SBI-553

Catalog No. T16860 CAS 1849603-72-0

SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).

SBI-553, CAS 1849603-72-0

Pack Size	Availability	Price/USD
1 mg	In stock	180.00
5 mg	In stock	343.00
10 mg	In stock	542.00
25 mg	In stock	972.00
50 mg	In stock	1608.00
100 mg	In stock	2203.00
1 mL * 10 mM (in DMSO)	In stock	361.00

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Purity 98.00%

COA Datasheet

Purity 99.69%

HNMR HPLC COA Datasheet

Biological Description

Chemical Properties

Storage & Solubility Information

Description	SBI-553 is an effective and brain penetrant NTR1 allosteric modulator (EC50: 0.34 μM).
Targets&IC50	NTR1 :ic50 （EC50）0.34 μM,

Molecular Weight	450.55
Formula	C26H31FN4O2
CAS No.	1849603-72-0

Storage

0-4℃ for short term (days to weeks), or -20℃ for long term (months).

Solubility Information

DMSO: 62.5 mg/mL (138.72 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Pinkerton AB, et al. Discovery of β-Arrestin Biased, Orally Bioavailable, and CNS Penetrant Neurotensin Receptor 1 (NTR1) Allosteric Modulators. J Med Chem. 2019 Aug 20.

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Answers to questions you may have can be found in the Inhibitor Handling Instructions. Topics include how to prepare stock solutions, how to store Products, and issues that need special attention for cell-based assays and animal experiments.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.