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SDZ281-977
SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
Catalog No. T16866Cas No. 150779-71-8
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Purity:99.64%
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SDZ281-977
Catalog No. T16866Alias SDZ-LAP 977Cas No. 150779-71-8
SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $100 | In Stock | |
| 5 mg | $247 | In Stock | |
| 10 mg | $396 | In Stock | |
| 25 mg | $793 | In Stock | |
| 50 mg | $1,230 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $272 | In Stock |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | SDZ 281-977 is a derivative of Lavendustin A, an EGF receptor tyrosine kinase inhibitor. |
| In vitro | The anticancer activity of SDZ 281-977 is evaluated in nude mice with human tumor cell lines A431 (vulvar carcinoma cells), MIA PaCa-2 (pancreatic tumor cells), and MDA-MB-231 (breast carcinoma cells). The IC50 values for growth inhibition of A431, MIA PaCa-2, and MDA-MB-231 cells are 0.21 μM, 0.29 μM, and 0.43 μM, respectively [1]. |
| In vivo | Intravenous administration of SDZ 281-977 (1-10 mg/kg) for 4 weeks in nude mice with A431 human vulvar carcinomas results in dose-dependent tumor growth inhibition. Additionally, oral administration of SDZ 281-977 (30 mg/kg) leads to a 54% inhibition of A431 tumor growth after 3 weeks of treatment [1]. |
| Alias | SDZ-LAP 977 |
| Molecular Weight | 316.35 |
| Formula | C18H20O5 |
| Cas No. | 150779-71-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 80 mg/mL (252.88 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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