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SK33
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
Catalog No. T12928Cas No. 1928724-23-5
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Purity:99.55%
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SK33
Catalog No. T12928Cas No. 1928724-23-5
SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity.
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $74 | In Stock | |
| 5 mg | $158 | In Stock | |
| 10 mg | $238 | In Stock | |
| 25 mg | $397 | In Stock | |
| 50 mg | $568 | In Stock | |
| 100 mg | $768 | In Stock | |
| 200 mg | $987 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $197 | In Stock |
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Product Introduction
Bioactivity
Chemical Properties
Storage & Solubility Information
| Description | SK33 is a potent and tissue selective anti-androgen agent. SK33 reduces androgen receptor (AR) transcriptional activity. |
| Targets&IC50 | LNCaPAR+ cells:0.2 μM |
| In vitro | SK33 has a significantly potent activity (IC50:0.2 μM) in LNCaPAR+ cells. SK33 decreases cells enter S-phase in LNCaP cells. In LNCaP/BicR cells, increasing concentrations of SK33 for 96 hours results in a dose-dependent response and an inhibition of cell growth(IC50 : 5 μM for SK33). |
| In vivo | AR transcriptional activity inhibited by SK33 after 50 mg/kg treatment for 24 hours. |
| Molecular Weight | 500.31 |
| Formula | C20H13F9N2O3 |
| Cas No. | 1928724-23-5 |
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (109.93 mM)  | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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