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SN50 acetate (213546-53-3 free base)

Catalog No. T12942L

SN50 acetate is a cell permeable inhibitor of NF-κB translocation.

SN50 acetate (213546-53-3 free base)

SN50 acetate (213546-53-3 free base)

Purity: 99.86%
Catalog No. T12942L
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
Pack SizePriceAvailabilityQuantity
1 mg$48In Stock
5 mg$196In Stock
10 mg$295In Stock
25 mg$472In Stock
50 mg$672In Stock
100 mg$893In Stock
200 mg$1,180In Stock
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Purity:99.86%
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Product Introduction

Bioactivity
Description
SN50 acetate is a cell permeable inhibitor of NF-κB translocation.
In vitro
Pretreatment with SN50 acetate results in a significant reduction in amount of PI-positive cells at 12, 24, and 48 h time-point post TBI compared with vehicle-treated groups[1]. Topical SN50 acetate suppresses nuclear factor-κB activation in local cells and reduces the incidence of epithelial defects/ulceration in healing corneas. Myofibroblast generation, macrophage invasion, activity of matrix metalloproteinases, basement membrane destruction, and expression of cytokines are all decreased in treated corneas compared with controls[2]. Treating the human gastric cancer cells SGC7901 with SN50 acetate could significantly enhance the effects of LY294002 on inducing cell death after 24 h[3]. SN50 can inhibit translocation of NF-kB and production of inflammatory cytokines that are implicated in lipopolysaccharide (LPS)-induced lung injury[4].
In vivo
Treatment with SN50 acetate accelerates the recovery of motor functional outcome from 1st to 4th day. Animals subjected to SN50 acetate pretreatment demonstrate a significant decrease in the visuospatial learning latencies relative to the control group at 7 and 8 days post-TBI. Pretreatment with SN50 acetate results in a significant reduction of NF-κB p65 protein levels from 6 to 48 h post-TBI and TNF-a protein levels from 12 to 48 h post-TBI[1].
Chemical Properties
Molecular Weight2841.55
FormulaC131H234N36O31S
Storage & Solubility Information
Storagekeep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
H2O: 10 mM
Solution Preparation Table
H2O
1mg5mg10mg50mg
1 mM0.3519 mL1.7596 mL3.5192 mL17.5960 mL
5 mM0.0704 mL0.3519 mL0.7038 mL3.5192 mL
10 mM0.0352 mL0.1760 mL0.3519 mL1.7596 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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