Powder: -20°C for 3 years | In solvent: -80°C for 1 year
SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM.
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 41.00 | |
5 mg | In stock | $ 97.00 | |
10 mg | In stock | $ 155.00 | |
25 mg | In stock | $ 313.00 | |
50 mg | In stock | $ 497.00 | |
100 mg | In stock | $ 723.00 | |
500 mg | In stock | $ 1,520.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 97.00 |
Description | SPP-86 is an effective and selective cell-permeable inhibitor of RET tyrosine kinase with an IC50 of 8 nM. |
Targets&IC50 | RET:8 nM |
In vitro | Administration of SPP-86 (0-10 μM) suppresses RET-induced phosphatidylinositide 3-kinases (PI3K)/Akt and MAPK signaling and estrogen receptorα (ERα) phosphorylation in MCF7 cells. Administration of SPP-86 (0-10 μM) also supppresses MAPK signaling and proliferation in RET/PTC1 expressing TPC1 compared to 8505C or C643 cells [1]. |
Molecular Weight | 277.32 |
Formula | C16H15N5 |
CAS No. | 1357349-91-7 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 100 mg/mL (360.59 mM), Sonication is recommended.
You can also refer to dose conversion for different animals. More
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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.
SPP-86 1357349-91-7 Apoptosis Tyrosine Kinase/Adaptors c-RET SPP 86 Inhibitor inhibit RET SPP86 inhibitor