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SR9243

Catalog No. T1801   CAS 1613028-81-1

SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
SR9243 Chemical Structure
SR9243, CAS 1613028-81-1
Pack Size Availability Price/USD Quantity
2 mg In stock $ 32.00
5 mg In stock $ 51.00
10 mg In stock $ 72.00
25 mg In stock $ 126.00
50 mg In stock $ 197.00
100 mg In stock $ 363.00
200 mg In stock $ 575.00
1 mL * 10 mM (in DMSO) In stock $ 68.00
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Purity: 99.03%
Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SR9243, an LXR inverse agonist, can induce LXR-corepressor interaction; shows anticancer activity and selectively targets the lipogenesis and Warburg effect.
In vitro In HEK293 cells expressing LXRs, SR9243 inhibits LXR activation by enhancing LXR-corepressor recruitment. In a variety of cancer cell types, SR9243 reduces cancer cell viability, induces apoptotic cell death, and sensitizes cancer cells to chemotherapeutic treatments. [1]
In vivo In Ob/Ob mice fed a high-fat diet, SR9243 (60 mg/kg, i.p.) inhibits LXR-dependent lipogenic enzyme gene expression and tumor growth. [1]
Kinase Assay ALK5 Fluorescence Polarization Binding Assay: GW788388 binding to ALK5 is tested on purified recombinant GST?ALK5 (residues 198-503). Displacement of rhodamine green fluorescently labeled ATP competitive inhibitor by different concentrations of GW788388 is used to calculate a binding pIC50. GST?ALK5 is added to a buffer containing 62.5 mM N-(2-hydroxyethyl)piperazine-N'-2-ethanesulfonic acid (Hepes), pH 7.5, 1 mM dithiothreitol (DTT), 12.5 mM MgCl2, 1.25 mM 3-[(3-cholamidopropyl)dimethylammonio]-1-propanesulfonic acid (CHAPS), and 1 nM rhodamine green-labeled ligand so that the final ALK5 concentration is 10 nM based on active-site titration of the enzyme. The enzyme/ligand reagent (40 μL) is added to 384-well assay plates containing 1 μL of different concentrations of GW788388. The plates are read immediately on a LJL Acquest fluorescence reader with excitation, emission, and dichroic filters of 485, 530, and 505 nm, respectively. The fluorescence polarization for each well is calculated by the Acquest and is then imported into curve-fitting software for construction of concentration?response curves.
Cell Research Cells are cultured in 96 well plates and treated with designated amounts of SR9243 for 96 hr in media containing 1% FBS and antibiotics. Cell-viability is assessed using the Cell-titre 96 kit according to the manufacturer's guidelines. Cell culture media is supplemented with oleate, stearate and palmitate dissolved in methanol to a concentration of 25 mM. 25 mM stocks are then diluted 10 fold in PBS containing 0.9% BSA. Lipid stocks (100X) are stored at ?20° until needed.(Only for Reference)
Molecular Weight 626.62
Formula C31H32BrNO4S2
CAS No. 1613028-81-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 12.5 mg/mL (20 mM)

TargetMolReferences and Literature

1. Flaveny CA, et al. Cancer Cell. 2015, 28(1), 42-56 2. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease[J]. Bioorganic chemistry. 2019 Mar;84:87-97.

TargetMolCitations

1. Capoci I R G, Faria D R, Sakita K M, et al. Repurposing approach identifies new treatment options for invasive fungal disease. Bioorganic Chemistry. 2019 Mar;84:87-97

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Active Compound Library Bioactive Lipid Compound Library Bioactive Compound Library Nuclear Receptor Compound Library NO PAINS Compound Library Anti-Cancer Compound Library PPI Inhibitor Library Lipid Metabolism Compound Library Bioactive Compounds Library Max Metabolism Compound Library

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Keywords

SR9243 1613028-81-1 Metabolism Liver X Receptor SR-9243 LXR Liver X receptor Inhibitor SR 9243 inhibit inhibitor

 

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