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SU14813

Catalog No. T7945   CAS 627908-92-3

SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).

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SU14813 Chemical Structure
SU14813, CAS 627908-92-3
Pack Size Availability Price/USD Quantity
5 mg In stock $ 47.00
10 mg In stock $ 80.00
25 mg In stock $ 146.00
50 mg In stock $ 247.00
100 mg In stock $ 397.00
1 mL * 10 mM (in DMSO) In stock $ 52.00
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Purity: 99.72%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
Targets&IC50 PDGFRβ:4 nM , Kit:15 nM, VEGFR1:2 nM , VEGFR2:50 nM
In vitro SU14813, a small molecule identified from the same chemical library used to isolate sunitinib, has broad-spectrum RTK inhibitory activity through binding to and inhibition of VEGFR, PDGFR, KIT, and FLT3.?In cellular assays, SU14813 inhibited ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets.?SU14813 inhibited VEGFR-2, PDGFR-beta, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion[1].
In vivo The plasma concentration required for in vivo target inhibition was estimated to be 100 to 200 ng/mL.?Used as monotherapy, SU14813 exhibited broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenografts derived from human or rat tumor cell lines.?Treatment in combination with docetaxel significantly enhanced both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone[1].
Molecular Weight 442.48
Formula C23H27FN4O4
CAS No. 627908-92-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 44 mg/mL (99.44 mM), sonification is recommended.

TargetMolReferences and Literature

1. Patyna S, et al. SU14813: a novel multiple receptor tyrosine kinase inhibitor with potent antiangiogenic and antitumor activity. Mol Cancer Ther. 2006 Jul;5(7):1774-82. 2. Dana Hu-Lowe ,et al.The Discovery and Development of SU14813, a Next-Generation Multitargeted Tyrosine Kinase Inhibitor for the Treatment of Human Malignancies.Mol Cancer Ther. 2011 Nov;10(11):2015.

Related compound libraries

This product is contained In the following compound libraries:
Tyrosine Kinase Inhibitor Library Anti-Lung Cancer Compound Library Cytokine Inhibitor Library Anti-Cancer Compound Library Bioactive Compound Library Bioactive Compounds Library Max Angiogenesis related Compound Library Anti-Cardiovascular Disease Compound Library Anti-Prostate Cancer Compound Library Inhibitor Library

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Vorolanib PD-089828 R1530 Eupatolide SU4312 Rigosertib Orantinib Dovitinib lactate hydrate

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Keywords

SU14813 627908-92-3 Angiogenesis Tyrosine Kinase/Adaptors VEGFR PDGFR c-Kit SU-14813 Inhibitor SU 14813 Vascular endothelial growth factor receptor CD117 Platelet-derived growth factor receptor inhibit SCFR inhibitor

 

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