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SU14813

SU14813
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
Catalog No. T7945Cas No. 627908-92-3
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Purity:99.72%
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SU14813

Purity: 99.72%
Catalog No. T7945Cas No. 627908-92-3

SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
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Pack SizePriceAvailabilityQuantity
5 mg$30In Stock
10 mg$48In Stock
25 mg$88In Stock
50 mg$148In Stock
100 mg$238In Stock
1 mL x 10 mM (in DMSO)$31In Stock
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Product Introduction

Bioactivity
Description
SU14813 is a multi-receptor tyrosine kinase inhibitor with potent antiangiogenesis and antitumor activity (IC50s of 50, 2, 4, 15 nM for VEGFR2, VEGFR1, PDGFRβ and KIT).
Targets&IC50
c-Kit:15 nM, PDGFRβ:4 nM , VEGFR1:2 nM , VEGFR2:50 nM
In vitro
SU14813, a small molecule identified from the same chemical library used to isolate sunitinib, has broad-spectrum RTK inhibitory activity through binding to and inhibition of VEGFR, PDGFR, KIT, and FLT3.?In cellular assays, SU14813 inhibited ligand-dependent and ligand-independent proliferation, migration, and survival of endothelial cells and/or tumor cells expressing these targets.?SU14813 inhibited VEGFR-2, PDGFR-beta, and FLT3 phosphorylation in xenograft tumors in a dose- and time-dependent fashion[1].
In vivo
The plasma concentration required for in vivo target inhibition was estimated to be 100 to 200 ng/mL.?Used as monotherapy, SU14813 exhibited broad and potent antitumor activity resulting in regression, growth arrest, or substantially reduced growth of various established xenografts derived from human or rat tumor cell lines.?Treatment in combination with docetaxel significantly enhanced both the inhibition of primary tumor growth and the survival of the tumor-bearing mice compared with administration of either agent alone[1].
Chemical Properties
Molecular Weight442.48
FormulaC23H27FN4O4
Cas No.627908-92-3
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 44 mg/mL (99.44 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2600 mL11.2999 mL22.5999 mL112.9995 mL
5 mM0.4520 mL2.2600 mL4.5200 mL22.5999 mL
10 mM0.2260 mL1.1300 mL2.2600 mL11.2999 mL
20 mM0.1130 mL0.5650 mL1.1300 mL5.6500 mL
50 mM0.0452 mL0.2260 mL0.4520 mL2.2600 mL

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