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Sacubitril/Valsartan

Catalog No. T2318 CAS 936623-90-4

Synonyms: Sacubitril mixture with Valsartan, Valsartan, Sacubitril, LCZ696

Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

Sacubitril/Valsartan, CAS 936623-90-4

Pack Size	Availability	Price/USD
2 mg	In stock	$ 38.00
5 mg	In stock	$ 61.00
10 mg	In stock	$ 85.00
25 mg	In stock	$ 126.00
50 mg	In stock	$ 158.00
100 mg	In stock	$ 198.00
500 mg	In stock	$ 492.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 100%

Purity: 99.94%

Purity: 99.88%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sacubitril/Valsartan (LCZ696) is an orally bioavailable, dual angiotensin II receptor and neprilysin inhibitor for the treatment of hypertension and heart failure.
In vitro	LCZ696 is a single molecule that is comprised of molecular moieties of valsartan, an ARB, and AHU377, a neprilysin inhibitor (1:1 ratio)[1].

Synonyms	Sacubitril mixture with Valsartan, Valsartan, Sacubitril, LCZ696
Molecular Weight	957.99
Formula	C48H55N6O8Na3.2.5H2O
CAS No.	936623-90-4

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

Ethanol: 9 mg/mL (9.82 mM), Heating is recommended.

H2O: 92 mg/mL (100.4 mM)

DMSO: 28 mg/mL (30.6 mM)

References and Literature

1. Huo H, et al. Erastin Disrupts Mitochondrial Permeability Transition Pore (mPTP) and Induces Apoptotic Death of Colorectal Cancer Cells. PLoS One. 2016 May 12;11(5):e20154605. 2. von Lueder TG, et al. Angiotensin receptor neprilysin inhibitor LCZ696 attenuates cardiac remodeling and dysfunction after myocardial infarction by reducing cardiac fibrosis and hypertrophy. Circ Heart Fail. 2015 Jan;8(1):71-8. 3. Bai HY, et al. Pre-treatment with LCZ696, an orally active angiotensin receptor neprilysin inhibitor, prevents ischemic brain damage. Eur J Pharmacol. 2015 Sep 5;762:293-8.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Drug Library Anti-Cancer Clinical Compound Library Drug Repurposing Compound Library Anti-Neurodegenerative Disease Compound Library Inhibitor Library Anti-Cancer Approved Drug Library Metabolism Compound Library Anti-Parkinson's Disease Compound Library Human Metabolite Library Clinical Compound Library

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Sacubitril/Valsartan 936623-90-4 Apoptosis Endocrinology/Hormones Metabolism Neprilysin RAAS hypertension Angiotensin Receptor orally Sacubitril mixture with Valsartan Cluster of differentiation 10 angiotensin receptor-neprilysin NEP Neutral endopeptidase inhibit ARN LCZ-696 Valsartan CD10 heart Inhibitor Sacubitril LCZ 696 LCZ696 inhibitor

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