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Sitagliptin phosphate monohydrate

Catalog No. T0242L CAS 654671-77-9

Synonyms: MK-0431, MK-0431 phosphate monohydrate

Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.

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Sitagliptin phosphate monohydrate Chemical Structure

Sitagliptin phosphate monohydrate, CAS 654671-77-9

Pack Size	Availability	Price/USD	Quantity
100 mg	In stock	$ 50.00
1 mL * 10 mM (in DMSO)	In stock	$ 50.00

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Purity: 99.65%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Sitagliptin phosphate monohydrate (MK-0431 phosphate monohydrate) is a potent inhibitor of DPP-IV with IC50 of 19 nM in Caco-2 cell extracts.
Targets&IC50	DPP4:19 nM
In vitro	The IC50 of Nelarabine is 25-fold and 113-fold higher than ARAC in T- and B-lineage, respectively. T-ALL cells are eightfold more sensitive to Nelarabine than B-lineage but there is considerable overlap. The efficacy of NEL in T-lineage and B-lineage cell lines is 25-fold and 113-fold less than ARAC, respectively. [1] Nelarabine acts by inhibiting DNA synthesis and inducing apoptosis in susceptible cells. [2]Nelarabine demonstrated significant antineoplastic activity with acceptable toxicity. [3]

Synonyms	MK-0431, MK-0431 phosphate monohydrate
Molecular Weight	523.32
Formula	C16H15F6N5O·H3PO4·H2O
CAS No.	654671-77-9

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: 38 mg/mL (72.6 mM)

Ethanol: < 1 mg/mL (insoluble or slightly soluble)

DMSO: 93 mg/mL (177.7 mM)

References and Literature

1. Thomas L et al. J Pharmacol Exp Ther. 2008; 325(1): 175-182. 2. Kim SJ et al. Diabetes. 2009; 58(3): 641-651.

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MUN57694 ML604440 M3258 Gly-Pro-pNA hydrochloride MG-101 DBPR108 Nateglinide MG-132

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

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