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T-3775440 hydrochloride

Catalog No. T13055 CAS 1422535-52-1

T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).

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T-3775440 hydrochloride Chemical Structure

T-3775440 hydrochloride, CAS 1422535-52-1

Pack Size	Availability	Price/USD
1 mg	In stock	$ 97.00
5 mg	In stock	$ 263.00
10 mg	In stock	$ 393.00
25 mg	In stock	$ 658.00
50 mg	In stock	$ 937.00
100 mg	In stock	$ 1,270.00
1 mL * 10 mM (in DMSO)	In stock	$ 257.00

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Purity: 99.94%

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Description	T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
Targets&IC50	LSD1:2.1 nM
In vitro	T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. Knockdown of LSD1 and GFI1B recapitulated T-3775440-induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1-GFI1B axis inhibition with regard to the anti-AML effects of T-3775440[1].
In vivo	T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models[1].

Molecular Weight	346.85
Formula	C18H23ClN4O
CAS No.	1422535-52-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30.18 mg/mL (87.01 mM)

References and Literature

1. Ishikawa Y, et al. A Novel LSD1 Inhibitor T-3775440 Disrupts GFI1B-Containing Complex Leading to Transdifferentiation and Impaired Growth of AML Cells. Mol Cancer Ther. 2017 Feb;16(2):273-284. 2. Matsumoto, Satoru, Ishikawa,et al. LSD1 Inhibitor T-3775440 Inhibits SCLC Cell Proliferation by Disrupting LSD1 Interactions with SNAG Domain Proteins INSM1 and GFI1B[J]. Cancer Research the Official Organ of the American Association for Cancer Research Inc, 2017.

Related compound libraries

This product is contained In the following compound libraries：

Highly Selective Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Bioactive Compound Library Chromatin Modification Compound Library Stem Cell Differentiation Compound Library Histone Modification Compound Library Epigenetics Compound Library Anti-Aging Compound Library NO PAINS Compound Library

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Keywords

T-3775440 hydrochloride 1422535-52-1 Chromatin/Epigenetic Histone Demethylase T3775440 hydrochloride T-3775440 inhibit T3775440 T 3775440 Inhibitor T 3775440 hydrochloride T 3775440 Hydrochloride T-3775440 Hydrochloride T3775440 Hydrochloride inhibitor

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