Powder: -20°C for 3 years | In solvent: -80°C for 1 year
T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM).
Pack Size | Availability | Price/USD | Quantity |
---|---|---|---|
1 mg | In stock | $ 97.00 | |
5 mg | In stock | $ 263.00 | |
10 mg | In stock | $ 393.00 | |
25 mg | In stock | $ 658.00 | |
50 mg | In stock | $ 937.00 | |
100 mg | In stock | $ 1,270.00 | |
1 mL * 10 mM (in DMSO) | In stock | $ 257.00 |
Description | T-3775440 hydrochloride is an irreversible inhibitor of lysine-specific histone demethylase (LSD1)(IC50 : 2.1 nM). |
Targets&IC50 | LSD1:2.1 nM |
In vitro | T-3775440, a novel irreversible LSD1 inhibitor. Cell growth analysis of leukemia cell lines revealed that acute erythroid leukemia (AEL) and acute megakaryoblastic leukemia cells (AMKL) were highly sensitive to this compound. T-3775440 treatment enforced transdifferentiation of erythroid/megakaryocytic lineages into granulomonocytic-like lineage cells. Mechanistically, T-3775440 disrupted the interaction between LSD1 and growth factor-independent 1B (GFI1B), a transcription factor critical for the differentiation processes of erythroid and megakaryocytic lineage cells. Knockdown of LSD1 and GFI1B recapitulated T-3775440-induced transdifferentiation and cell growth suppression, highlighting the significance of LSD1-GFI1B axis inhibition with regard to the anti-AML effects of T-3775440[1]. |
In vivo | T-3775440 exhibited significant antitumor efficacy in AEL and AMKL xenograft models[1]. |
Molecular Weight | 346.85 |
Formula | C18H23ClN4O |
CAS No. | 1422535-52-1 |
Powder: -20°C for 3 years | In solvent: -80°C for 1 year
DMSO: 30.18 mg/mL (87.01 mM)
You can also refer to dose conversion for different animals. More
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