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TAE-1

Catalog No. T21825   CAS 1414469-59-2

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.

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TAE-1 Chemical Structure
TAE-1, CAS 1414469-59-2
Pack Size Availability Price/USD Quantity
10 mg In stock $ 39.00
25 mg In stock $ 89.00
50 mg In stock $ 155.00
100 mg In stock $ 228.00
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Purity: 98%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Targets&IC50 AChE:0.3 μM
In vitro The effects of TAE-1 on differentiated human SH-SY5Y neuronal cells grown in tissue culture.?Results showed that the stimulation of neuronal cellular process length and branching was noted.?Moreover, the increased synaptophysin suggested that TAE-1 could stimulate synapse formation.?Increased expression of MAP2 was also observed, indicating that TAE-1 promoted the differentiation of human neurons.?In addition, targeted AChE inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes.?It was found that at increasing TAE-1concentrations, there was a corresponding decrease in the AChE activity resulting in reduced amount of oxidizable thiocholine.?The IC50 value was found to be 0.465 μM for TAE-1[1]
Molecular Weight 1128.57
Formula C39H51I3N6O9
CAS No. 1414469-59-2

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 11.29 mg/mL (10 mM), Sonification is recommended

TargetMolReferences and Literature

1. Biological activity of sym-triazines with acetylcholine-like substitutions as multitarget modulators of Alzheimer's disease.[J]. Acs Chemical Neuroscience, 2013, 4(6):924-9. 2. Veloso A J , Chow A M , Ganesh H , et al. Electrochemical Immunosensors for Effective Evaluation of Amyloid-Beta Modulators on Oligomeric and Fibrillar Aggregation Processes[J]. Analytical Chemistry, 2014, 86(10):4901-9.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Neurodegenerative Disease Compound Library Bioactive Compounds Library Max Neurotransmitter Receptor Compound Library Anti-Alzheimer's Disease Compound Library Neuronal Signaling Compound Library Inhibitor Library Bioactive Compound Library NO PAINS Compound Library

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Keywords

TAE-1 1414469-59-2 Neuroscience Beta Amyloid AChE β-amyloid peptide inhibit TAE 1 Cholinesterase (ChE) Amyloid-β Abeta TAE1 Inhibitor inhibitor

 

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