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TAE-1

Catalog No. T21825Cas No. 1414469-59-2

TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.

TAE-1

TAE-1

Catalog No. T21825Cas No. 1414469-59-2
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Pack SizePriceAvailabilityQuantity
25 mg$53In Stock
50 mg$93In Stock
100 mg$137In Stock
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Purity:≥95%
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Product Introduction

Bioactivity
Description
TAE-1 is an inhibitor of amyloid-β fibril formation and aggregation. It inhibits cholinesterases AChE and BuChE with IC50 of 0.3 μM and 3.9 μM, respectively.
Targets&IC50
AChE:0.3 μM
In vitro
The effects of TAE-1 on differentiated human SH-SY5Y neuronal cells grown in tissue culture.?Results showed that the stimulation of neuronal cellular process length and branching was noted.?Moreover, the increased synaptophysin suggested that TAE-1 could stimulate synapse formation.?Increased expression of MAP2 was also observed, indicating that TAE-1 promoted the differentiation of human neurons.?In addition, targeted AChE inhibition was evaluated by electrochemical quantification of the enzymatic product, thiocholine, on unmodified gold screen-printed electrodes.?It was found that at increasing TAE-1concentrations, there was a corresponding decrease in the AChE activity resulting in reduced amount of oxidizable thiocholine.?The IC50 value was found to be 0.465 μM for TAE-1[1]
Chemical Properties
Molecular Weight1128.57
FormulaC39H51I3N6O9
Cas No.1414469-59-2
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 11.29 mg/mL (10 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM0.8861 mL4.4304 mL8.8608 mL44.3039 mL
5 mM0.1772 mL0.8861 mL1.7722 mL8.8608 mL
10 mM0.0886 mL0.4430 mL0.8861 mL4.4304 mL

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