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TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | $31 | In Stock | |
10 mg | $53 | In Stock | |
25 mg | $112 | In Stock | |
50 mg | $192 | In Stock | |
100 mg | $333 | In Stock | |
200 mg | $479 | In Stock | |
1 mL x 10 mM (in DMSO) | $34 | In Stock |
Description | TCN238 is an orally bioavailable positive allosteric modulator of the metabotropic glutamate receptor 4 (mGluR4with an EC50 of 1 μM). |
Targets&IC50 | mGlu4 receptor:1 μM (EC50) |
In vitro | TCN238 has a greater than 30-fold selectivity for mGluR4 over mGluR5 using human recombinant receptors in CHO-K1 cells[1]. |
In vivo | TCN238 has no activity at the adenosine A2A, serotonin 5-HT1A, or α2A-adrenergic receptors at concentrations up to 10 μM.?In a haloperidol-induced catalepsy rat model of Parkinson's disease, it dose-dependently reduces catalepsy with an ED50 of approximately 1 mg/kg.?TCN 238 administration in rats leads to downregulation of the mGluR4 gene, GRM4, in the hippocampus and the gene for the GABAA receptor α subunit, GABRA1, in the frontal cortex without affecting hippocampal-dependent memory[1]. |
Alias | TCN 238 |
Molecular Weight | 197.24 |
Formula | C12H11N3 |
Cas No. | 125404-04-8 |
Smiles | Nc1nccc(\C=C\c2ccccc2)n1 |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 150 mg/mL (760.49 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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