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TH34

Catalog No. T5332 CAS 2196203-96-8

TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.

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TH34, CAS 2196203-96-8

Pack Size	Availability	Price/USD
1 mg	In stock	$ 38.00
5 mg	In stock	$ 89.00
10 mg	In stock	$ 128.00
25 mg	In stock	$ 272.00
50 mg	In stock	$ 438.00
100 mg	In stock	$ 597.00
1 mL * 10 mM (in DMSO)	In stock	$ 98.00

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Purity: 98.77%

Biological Description

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Storage & Solubility Information

Description	TH34 is an HDAC6/8/10 inhibitor (IC50s: 4.6/1.9/7.7 μM). It shows high selectivity over HDAC1/2/3.
Targets&IC50	HDAC6:4.6 μM, HDAC8:1.9 μM, HDAC10:7.7 μM
In vitro	TH34 is well-tolerated by non-transformed human skin fibroblasts at concentrations up to 25 μM and modestly impairs colony growth in medulloblastoma cell lines, but specifically induces caspase-dependent programmed cell death in a concentration-dependent manner in several human neuroblastoma cell lines.
Cell Research	HeLa cells, stably transfected with NanoBRET plasmids NanoLuc?-HDAC6 FL Fusion Vector and NanoLuc?-HDAC10 FL Fusion Vector were seeded at 20,000 cells/well in white 96-well plates. Without further incubation, tracer (0.3 μM) and drugs were added in separate steps and plates were placed in a tissue culture incubator for 2 h. For NanoBRET quantification, plates were put at room temperature for 10 min. Nanoglow substrate, diluted in OptiMEM without phenol red, was added and measured within 10 min in an OPTIMA plate reader (460 nm emission for donor and 610LP filter for acceptor). The BRET signal was calculated by the ratio of acceptor signal to donor signal.

Molecular Weight	256.3
Formula	C15H16N2O2
CAS No.	2196203-96-8

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

H2O: Insoluble

DMSO: 80 mg/mL (312.13 mM)

References and Literature

1. Kolbinger FR, et al. The HDAC6/8/10 inhibitor TH34 induces DNA damage-mediated cell death in human high-grade neuroblastoma cell lines. Arch Toxicol. 2018 Aug;92(8):2649-2664.

Related compound libraries

This product is contained In the following compound libraries：

Inhibitor Library Bioactive Compound Library Anti-Pancreatic Cancer Compound Library Anti-Cancer Compound Library Epigenetics Compound Library Histone Modification Compound Library Anti-Breast Cancer Compound Library Chromatin Modification Compound Library DNA Damage & Repair Compound Library NO PAINS Compound Library

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Related compounds with same targets

HDAC6-IN-23 EDO-S101 NSC 3852 RG2833 Vorinostat Tubastatin A Hydrochloride ACY-775 PTACH

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

TH34 2196203-96-8 Chromatin/Epigenetic DNA Damage/DNA Repair HDAC TH 34 TH-34 inhibit Inhibitor Histone deacetylases inhibitor

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