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Taccalonolide B

Catalog No. TN2256   CAS 108885-69-4

Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.

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Taccalonolide B Chemical Structure
Taccalonolide B, CAS 108885-69-4
Pack Size Availability Price/USD Quantity
1 mg In stock $ 80.00
5 mg In stock $ 197.00
10 mg In stock $ 338.00
25 mg In stock $ 566.00
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Purity: 99.69%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description Taccalonolide B is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug-resistance protein (MRP7). Taccalonolide B inhibits growth of SK-OV-3 cells with an IC50 of 208 nM.
In vitro The structures were elucidated using a combination of spectroscopic methods, including 1D and 2D NMR and HR-ESI-MS. Taccalonolide AJ, an epoxidation product of Taccalonolide B, was generated by semisynthesis. Five of these taccalonolides demonstrated cellular microtubule-stabilizing activities and antiproliferative actions against cancer cells, with taccalonolide AJ exhibiting the highest potency with an IC50 value of 4.2 nM. The range of potencies of these compounds, from 4.2 nM to >50 μM, for the first time provides the opportunity to identify specific structural moieties crucial for potent biological activities as well as those that impede optimal cellular effects. In mechanistic assays, taccalonolides AF and AJ stimulated the polymerization of purified tubulin, an activity that had not previously been observed for taccalonolides A and B, providing the first evidence that this class of microtubule stabilizers can interact directly with tubulin/microtubules. Taccalonolides AF and AJ were able to enhance tubulin polymerization to the same extent as paclitaxel but exhibited a distinct kinetic profile, suggesting a distinct binding mode or the possibility of a new binding site.
Source
Molecular Weight 660.71
Formula C34H44O13
CAS No. 108885-69-4

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

TargetMolReferences and Literature

1. Potent Taccalonolides, AF and AJ, Inform Significant Structure€“Activity Relationships and Tubulin as the Binding Site of These Microtubule StabilizersJ. Am. Chem. Soc., 2011, 133 (47), pp 19064€“19067

Related compound libraries

This product is contained In the following compound libraries:
Natural Product Library for HTS

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Keywords

Taccalonolide B 108885-69-4 Cytoskeletal Signaling Microtubule Associated inhibit Microtubule/Tubulin Inhibitor inhibitor

 

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