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Talibegron hydrochloride

Catalog No. T23557 CAS 178600-17-4

Synonyms: ZD2079 hydrochloride

Talibegron hydrochloride is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.

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Talibegron hydrochloride, CAS 178600-17-4

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Purity: 98%

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Description	Talibegron hydrochloride is an β3 adrenergic receptor agonist with a pD2 of 3.72 on phenylephrine-preconstricted rat mesenteric artery. Relaxes rat mesenteric artery and isolated aorta in vitro. Inhibits ob gene expression and circulating leptin levels in lean mice in vivo.
In vitro	Talibegron hydrochloride ( 0.01-1000 μM) produces a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries and causes full relaxation with 1 mM[1].
In vivo	The β3-adrenoceptor agonist talibegron hydrochloride produced a concentration-dependent relaxation of phenylephrine-preconstricted isolated mesenteric arteries. The shape of the concentration–response curve of talibegron hydrochloride also suggests that this drug, which was studied up to 1 mm, causes full relaxation [3].

Synonyms	ZD2079 hydrochloride
Molecular Weight	351.83
Formula	C18H22ClNO4
CAS No.	178600-17-4

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

H2O: <8.8mg/ml

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Hanna Kozłowska, et al. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol. 2003 Sep;140(1):3-12. 2. Brawley L, et al. Role of endothelium/nitric oxide in atypical beta-adrenoceptor-mediated relaxation in rat isolated aorta. Eur J Pharmacol. 2000 Jun 16;398(2):285-96. 3. Kozłowska H, et al. Atypical beta-adrenoceptors, different from beta 3-adrenoceptors and probably from the low-affinity state of beta 1-adrenoceptors, relax the rat isolated mesenteric artery. Br J Pharmacol. 2003 Sep;140(1):3-12.

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Keywords

Talibegron hydrochloride 178600-17-4 GPCR/G Protein Neuroscience Adrenergic Receptor ZD2079 hydrochloride Inhibitor inhibitor inhibit

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