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Tandospirone
Tandospirone (SM-3997) is a selective partial agonist of the 5-HT1A receptor (Ki: 27 nM) with marked selectivity over SR-2, SR-1C, α1, α2, D1, and D2 receptors (Kis: 1300-41000 nM).
Catalog No. TQ0315Cas No. 87760-53-0
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Tandospirone
Catalog No. TQ0315Cas No. 87760-53-0
Tandospirone (SM-3997) is a selective partial agonist of the 5-HT1A receptor (Ki: 27 nM) with marked selectivity over SR-2, SR-1C, α1, α2, D1, and D2 receptors (Kis: 1300-41000 nM).
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose. | Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $40 | 5 days | |
| 1 mL x 10 mM (in DMSO) | $98 | 5 days |
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CitedProduct Introduction
Bioactivity
Chemical Properties
| Description | Tandospirone (SM-3997) is a selective partial agonist of the 5-HT1A receptor (Ki: 27 nM) with marked selectivity over SR-2, SR-1C, α1, α2, D1, and D2 receptors (Kis: 1300-41000 nM). |
| Targets&IC50 | 5-HT1A:27 nM (Ki) |
| In vitro | Tandospirone is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors [1]. 3H-SM-3997 bound rapidly, reversibly and in a saturable manner with high affinity to rat brain hippocampal membranes (Kd: 9.4 nM, Bmax = 213 fmol/mg protein) [2]. |
| In vivo | Chronic treatment with tandospirone, at 0.2 and 1.0mg/kg/day, but not 2.0mg/kg/day, attenuated footshock stress-induced eLAC elevation in the mPFC [3]. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner [4]. |
| Alias | SM-3997 |
| Molecular Weight | 383.49 |
| Formula | C21H29N5O2 |
| Cas No. | 87760-53-0 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
| Solubility Information | H2O: Insoluble DMSO: 30 mg/mL |
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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