Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM).
Description | Tandospirone (SM-3997) is a selective partial agonist of 5-HT1A receptor (Ki: 27 nM) that displays selectivity over SR-2, SR-1C, α1, α2, D1 and D2 receptors (Kis: 1300-41000 nM). |
Targets&IC50 | 5-HT1A:27 nM (Ki) |
In vitro | Tandospirone is essentially inactive at 5-HT1B receptors; 5-HT uptake sites; beta-adrenergic, muscarinic cholinergic, and benzodiazepine receptors [1]. 3H-SM-3997 bound rapidly, reversibly and in a saturable manner with high affinity to rat brain hippocampal membranes (Kd: 9.4 nM, Bmax = 213 fmol/mg protein) [2]. |
In vivo | Chronic treatment with tandospirone, at 0.2 and 1.0mg/kg/day, but not 2.0mg/kg/day, attenuated footshock stress-induced eLAC elevation in the mPFC [3]. Rats were acutely administered tandospirone (0, 0.1, and 1 mg/kg, i.p.). Tandospirone decreased the number of premature responses, an index of impulsive action, in a dose-dependent manner [4]. |
Synonyms | 坦度螺酮, SM-3997 |
Molecular Weight | 383.49 |
Formula | C21H29N5O2 |
CAS No. | 87760-53-0 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
H2O: Insoluble
DMSO: 30 mg/mL
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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Tandospirone 87760-53-0 G蛋白偶联受体 神经科学 5-HT Receptor SM-3997 Inhibitor inhibitor inhibit