Home Tools
Log in
Cart

Torcetrapib

Catalog No. T2499   CAS 262352-17-0
Synonyms: CP-529414

Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to excess deaths.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.
Torcetrapib Chemical Structure
Torcetrapib, CAS 262352-17-0
Pack Size Availability Price/USD Quantity
1 mg In stock $ 37.00
2 mg In stock $ 50.00
5 mg In stock $ 72.00
10 mg In stock $ 98.00
25 mg In stock $ 206.00
50 mg In stock $ 383.00
100 mg In stock $ 568.00
1 mL * 10 mM (in DMSO) In stock $ 112.00
Bulk Inquiry
Get quote
Select Batch  
Purity: 99.2%
Purity: 98.91%
Purity: 98%
Contact us for more batch information
Biological Description
Chemical Properties
Storage & Solubility Information
Description Torcetrapib (CP-529414) is a cholesteryl ester transfer protein (CETP) inhibitor that reduces the heterotypic transfer of cholesteryl ester from HDL to LDL and/or VLDL. Torcetrapib failed in phase III trials due to excess deaths.
Targets&IC50 CETP:37 nM
In vitro In healthy young adults, daily doses of Torcetrapib at 10 mg, 30 mg, 60 mg, 120 mg, and twice daily at 120 mg increased plasma high-density lipoprotein cholesterol (HDL-C) levels by 16%, 28%, 62%, 73%, and 91%, respectively, without significant changes in total plasma cholesterol (TPC). In rabbits fed an atherogenic diet, Torcetrapib (90 mg/kg/day) more than tripled the plasma HDL-C levels and increased apoA-I levels by 2.5 times. For healthy individuals and patients with moderate hypercholesterolemia, 60 mg and 120 mg daily doses of Torcetrapib raised HDL cholesterol levels by 50% and 60%, respectively. The 60 mg daily dosage enhanced HDL-mediated net cholesterol efflux primarily by increasing HDL concentration, whereas the 120 mg daily dosage did so both by raising HDL concentration and by enhancing efflux at matched HDL concentrations. In the healthy young adult group, taking less than 100 mg of Torcetrapib altered the plasma distribution of cholesteryl ester transfer protein (CETP) 2 hours post-administration, as evidenced by an apparent shift in CETP to larger molecular forms. For patients at high risk of cardiovascular disease, 12 hours post-treatment with Torcetrapib led to a 72.1% increase in HDL-C, a 24.9% decrease in low-density lipoprotein cholesterol (LDL-C), a rise in systolic blood pressure of 5.4 mm Hg, and alterations in serum potassium, sodium, bicarbonate, and aldosterone concentrations.
In vivo Torcetrapib (1 μM) significantly enhances the expression of the steroidogenic genes CYP11B2 and CYP11B1 in the H295R cell line. Treatment with Torcetrapib for 24 or 48 hours increases aldosterone release from H295R cells in a dose-dependent manner, with an EC50 of approximately 80 nM. This effect is mediated by calcium channels, as calcium channel blockers completely inhibit the corticosteroid release and calcium increase induced by Torcetrapib.
Synonyms CP-529414
Molecular Weight 600.47
Formula C26H25F9N2O4
CAS No. 262352-17-0

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 30 mg/mL (50 mM)

TargetMolReferences and Literature

1. Clark RW, et al. Arterioscler Thromb Vasc Biol, 2004, 24(3), 490-497. 2. Hu X, et al. Endocrinology, 2009, 150(5), 2211-2219. 3. Barter PJ, et al. N Engl J Med, 2007, 357(21), 2109-2122. 4. Yvan-Charvet L, et al. Arterioscler Thromb Vasc Biol, 2007, 27(5), 1132-1138. 5. Morehouse LA, et al. J Lipid Res, 2007, 48(6), 1263-1272.

Related compound libraries

This product is contained In the following compound libraries:
Drug Repurposing Compound Library Metabolism Compound Library Bioactive Lipid Compound Library ReFRAME Related Library Bioactive Compounds Library Max Fluorochemical Library Inhibitor Library Anti-Obesity Compound Library Anti-Cardiovascular Disease Compound Library Lipid Metabolism Compound Library

Related Products

Related compounds with same targets
TAP311 Anacetrapib Lomitapide Evacetrapib CP-532623 Implitapide BMS-212122 Granotapide

TargetMolDose Conversion

You can also refer to dose conversion for different animals. More

TargetMol In vivo Formulation Calculator (Clear solution)

Step One: Enter information below
Dosage
mg/kg
Average weight of animals
g
Dosing volume per animal
ul
Number of animals
Step Two: Enter the in vivo formulation
% DMSO
%
% Tween 80
% ddH2O
Calculate Reset

TargetMolCalculator

Molarity Calculator
Dilution Calculator
Reconstitution Calculation
Molecular Weight Calculator
=
X
X

Molarity Calculator allows you to calculate the

  • Mass of a compound required to prepare a solution of known volume and concentration
  • Volume of solution required to dissolve a compound of known mass to a desired concentration
  • Concentration of a solution resulting from a known mass of compound in a specific volume
See Example

An example of a molarity calculation using the molarity calculator
What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
Enter 197.13 into the Molecular Weight (MW) box
Enter 10 into the Concentration box and select the correct unit (millimolar)
Enter 10 into the Volume box and select the correct unit (milliliter)
Press calculate
The answer of 19.713 mg appears in the Mass box

X
=
X

Calculator the dilution required to prepare a stock solution

Calculate the dilution required to prepare a stock solution
The dilution calculator is a useful tool which allows you to calculate how to dilute a stock solution of known concentration. Enter C1, C2 & V2 to calculate V1.

See Example

An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
Enter 10 into the Concentration (start) box and select the correct unit (millimolar)
Enter 50 into the Concentration (final) box and select the correct unit (micromolar)
Enter 20 into the Volume (final) box and select the correct unit (milliliter)
Press calculate
The answer of 100 microliter (0.1 ml) appears in the Volume (start) box

=
/

Calculate the volume of solvent required to reconstitute your vial.

The reconstitution calculator allows you to quickly calculate the volume of a reagent to reconstitute your vial.
Simply enter the mass of reagent and the target concentration and the calculator will determine the rest.

g/mol

Enter the chemical formula of a compound to calculate its molar mass and elemental composition

Tip: Chemical formula is case sensitive: C10H16N2O2 c10h16n2o2

Instructions to calculate molar mass (molecular weight) of a chemical compound:
To calculate molar mass of a chemical compound, please enter its chemical formula and click 'Calculate'.
Definitions of molecular mass, molecular weight, molar mass and molar weight:
Molecular mass (molecular weight) is the mass of one molecule of a substance and is expressed n the unified atomic mass units (u). (1 u is equal to 1/12 the mass of one atom of carbon-12)
Molar mass (molar weight) is the mass of one mole of a substance and is expressed in g/mol.

bottom

Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Torcetrapib 262352-17-0 Metabolism CETP high-density cholesterol inhibit plasma CP 529414 low-density cholesteryl CP-529414 Inhibitor lipoprotein LDL HDL transfer triglycerides protein ester Cholesteryl ester transfer protein VLDL CP529414 lipoprotein inhibitor

 

TargetMol