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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $499 | In Stock | |
2 mg | $599 | In Stock |
Description | Troleandomycin (Triacetyloleandomycin), a macrolide antibiotic, is an orally active and specific CYP3A inhibitor that induces mnemonic speech, induces prolonged cholestasis, and can be used in the study of asthma. |
In vitro | Troleandomycin significantly inhibits microsomal side chain hydroxylation in mouse and human livers in a dose-dependent manner. [1] |
In vivo | Troleandomycin significantly inhibits the 6β-hydroxylation of testosterone, the 25- and 26-hydroxylation of 5β-cholestane-3α, 7α, and 12α-triol, and the 23R-, 24R-, 24R-, 5β-cholestane-3α, 7α 24S- and 27-hydroxylation, 12α, 25-tetrol in recombinant CYP3A4 and microsomes, but the IC50 value of microsomes is slightly higher than that of recombinant CYP3A4.[2] |
Alias | AI3-50166, Triacetyloleandomycin, Aovine, Micotil, Matromycin T, Cyclamycin |
Molecular Weight | 813.97 |
Formula | C41H67NO15 |
Cas No. | 2751-09-9 |
Storage | store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (61.43 mM), Sonication is recommended. | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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