Powder: -20°C for 3 years
In solvent: -80°C for 2 years
Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively)
Description | Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor(KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively) |
Targets&IC50 | PDGFRα:4 nM , KDR:20 nM , FGFR1:2 nM , Flt-1:4 nM |
In vivo | Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats |
Synonyms | Tyrosine kinase IN 1, FGFR, Inhibitor, VEGFR, Platelet-derived growth factor receptor, Vascular endothelial growth factor receptor, Fibroblast growth factor receptor, inhibit, PDGFR, Tyrosine kinaseIN1 |
Molecular Weight | 445.542 |
Formula | C26H28FN5O |
CAS No. | 705946-27-6 |
Powder: -20°C for 3 years
In solvent: -80°C for 2 years
DMSO: 62.5 mg/mL (160.47 mM)
( < 1 mg/ml refers to the product slightly soluble or insoluble )
You can also refer to dose conversion for different animals. More
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