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Tyrosine kinase-IN-1

Catalog No. T5466 CAS 705946-27-6

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, FLT-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）

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Tyrosine kinase-IN-1, CAS 705946-27-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）
Targets&IC50	KDR:20 nM , FGFR1:2 nM , Flt-1:4 nM , PDGFRα:4 nM
In vivo	Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats

Molecular Weight	445.54
Formula	C26H28FN5O
CAS No.	705946-27-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 62.5 mg/mL (160.47 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

Tyrosine kinase-IN-1 705946-27-6 Angiogenesis Tyrosine Kinase/Adaptors VEGFR FGFR FLT PDGFR Tyrosine kinase IN 1 Inhibitor Platelet-derived growth factor receptor Vascular endothelial growth factor receptor Fibroblast growth factor receptor inhibit Tyrosine kinaseIN1 inhibitor

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