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Tyrosine kinase-IN-1

Catalog No. T5466 CAS 705946-27-6

Synonyms: Tyrosine kinase IN 1, FGFR, Inhibitor, VEGFR, Platelet-derived growth factor receptor, Vascular endothelial growth factor receptor, Fibroblast growth factor receptor, inhibit, PDGFR, Tyrosine kinaseIN1

Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）

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Tyrosine kinase-IN-1, CAS 705946-27-6

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	Tyrosine kinase-IN-1 is a multi-targeted tyrosine kinase inhibitor（KDR, Flt-1, FGFR1 and PDGFRα with IC50s of 4nM, 20nM, 4nM, 2 nM ,respectively）
Targets&IC50	PDGFRα:4 nM , KDR:20 nM , FGFR1:2 nM , Flt-1:4 nM
In vivo	Tyrosine kinase-IN-1 shows a reasonable PK profile (AUC(0–∞)=1.9, t1/2=4.6 h). It has a favorable oral bioavailability (F=63%) in rats

Synonyms	Tyrosine kinase IN 1, FGFR, Inhibitor, VEGFR, Platelet-derived growth factor receptor, Vascular endothelial growth factor receptor, Fibroblast growth factor receptor, inhibit, PDGFR, Tyrosine kinaseIN1
Molecular Weight	445.542
Formula	C26H28FN5O
CAS No.	705946-27-6

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 62.5 mg/mL (160.47 mM)

( < 1 mg/ml refers to the product slightly soluble or insoluble )

Citations

References and Literature

1. Moon K, et al. The design, synthesis, and biological evaluation of potent receptor tyrosine kinase inhibitors. Bioorganic & Medicinal Chemistry Letters 22 (2012) 4979–4985

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Compound Library Anti-Pancreatic Cancer Compound Library Inhibitor Library Covalent Inhibitor Library Anti-COVID-19 Compound Library Anti-Breast Cancer Compound Library Kinase Inhibitor Library Epigenetics Compound Library Angiogenesis related Compound Library Anti-Fibrosis Compound Library

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.