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VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $31 | In Stock | |
2 mg | $44 | In Stock | |
5 mg | $72 | In Stock | |
10 mg | $128 | In Stock | |
25 mg | $249 | In Stock | |
50 mg | $448 | In Stock | |
100 mg | $658 | In Stock | |
1 mL x 10 mM (in DMSO) | $79 | In Stock |
Description | VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM). |
Targets&IC50 | mGlu7:347 nM |
In vitro | Compared to the other seven mGlu receptor subtypes, VU6012962 is highly selective for mGlu7. |
In vivo | In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety . |
Molecular Weight | 448.4 |
Formula | C21H19F3N4O4 |
Cas No. | 2313526-86-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 125 mg/mL (278.77 mM), Sonication is recommended. H2O: < 0.1 mg/mL (insoluble) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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