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VU6012962

Catalog No. T13323Cas No. 2313526-86-0

VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).

VU6012962

VU6012962

Purity: 98.31%
Catalog No. T13323Cas No. 2313526-86-0
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Pack SizePriceAvailabilityQuantity
1 mg$31In Stock
2 mg$44In Stock
5 mg$72In Stock
10 mg$128In Stock
25 mg$249In Stock
50 mg$448In Stock
100 mg$658In Stock
1 mL x 10 mM (in DMSO)$79In Stock
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Purity:98.31%
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Product Introduction

Bioactivity
Description
VU6012962 is an orally bioavailable negative allosteric modulator of CNS-penetrant metabotropic glutamate receptor 7(mGlu7; IC50: 347 nM).
Targets&IC50
mGlu7:347 nM
In vitro
Compared to the other seven mGlu receptor subtypes, VU6012962 is highly selective for mGlu7.
In vivo
In the elevated zero maze (EZM) assay in mice, VU6012962 (1-10 mg/kg; i.p. injection; 60 minutes prior to testing) decreases anxiety .
Chemical Properties
Molecular Weight448.4
FormulaC21H19F3N4O4
Cas No.2313526-86-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 125 mg/mL (278.77 mM), Sonication is recommended.
H2O: < 0.1 mg/mL (insoluble)
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.2302 mL11.1508 mL22.3015 mL111.5076 mL
5 mM0.4460 mL2.2302 mL4.4603 mL22.3015 mL
10 mM0.2230 mL1.1151 mL2.2302 mL11.1508 mL
20 mM0.1115 mL0.5575 mL1.1151 mL5.5754 mL
50 mM0.0446 mL0.2230 mL0.4460 mL2.2302 mL
100 mM0.0223 mL0.1115 mL0.2230 mL1.1151 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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