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VX-984

Catalog No. T11067   CAS 1476074-39-1
Synonyms: M9831

VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.

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VX-984 Chemical Structure
VX-984, CAS 1476074-39-1
Pack Size Availability Price/USD Quantity
1 mg In stock $ 177.00
5 mg In stock $ 455.00
10 mg In stock $ 672.00
25 mg In stock $ 1,060.00
50 mg In stock $ 1,430.00
100 mg In stock $ 1,920.00
500 mg In stock $ 3,850.00
1 mL * 10 mM (in DMSO) In stock $ 490.00
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Purity: 97.65%
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Biological Description
Chemical Properties
Storage & Solubility Information
Description VX-984 (M9831) is an oral, selective DNA-PK inhibitor that can cross the blood-brain barrier. VX-984 inhibited the conjugation of non-homologous terminal NHEJ and acted on DSBs to break DNA double strand. VX-984 is commonly seen in glioblastoma (GBM) and non-small cell lung cancer (NSC-LC) studies.
Synonyms M9831
Molecular Weight 415.49
Formula C23H21D2N7O
CAS No. 1476074-39-1

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 9.0 mg/mL (21.7 mM), sonification is recommended.

TargetMolReferences and Literature

1. Atif J Khan, et al. VX-984 is a selective inhibitor of non-homologous end joining, with possible preferential activity in transformed cells. Oncotarget. 2018 May 25;9(40):25833-25841. 2. Cindy R Timme , et al. The DNA-PK Inhibitor VX-984 Enhances the Radiosensitivity of Glioblastoma Cells Grown In Vitro and as Orthotopic Xenografts. Mol Cancer Ther. 2018 Jun;17(6):1207-1216.

Related compound libraries

This product is contained In the following compound libraries:
Anti-Cancer Drug Library Anti-Cancer Active Compound Library Anti-Cancer Clinical Compound Library Anti-Obesity Compound Library Bioactive Compounds Library Max Inhibitor Library DNA Damage & Repair Compound Library Bioactive Compound Library Clinical Compound Library Anti-Cancer Compound Library

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Keywords

VX-984 1476074-39-1 DNA Damage/DNA Repair PI3K/Akt/mTOR signaling DNA-PK M 9831 VX984 M9831 VX 984 M-9831 inhibitor inhibit

 

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