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WHI-P180

Catalog No. T2032 CAS 211555-08-7

Synonyms: Janex 3

WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.

All products from TargetMol are for Research Use Only. Not for Human or Veterinary or Therapeutic Use.

WHI-P180, CAS 211555-08-7

Pack Size	Availability	Price/USD
1 mg	In stock	$ 40.00
2 mg	In stock	$ 57.00
5 mg	In stock	$ 94.00
10 mg	In stock	$ 138.00
25 mg	In stock	$ 233.00
50 mg	In stock	$ 346.00
100 mg	In stock	$ 512.00
1 mL * 10 mM (in DMSO)	In stock	$ 89.00

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Purity: 97.74%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	WHI-P180 (Janex 3) is a potent EGFR and Cdk2 inhibitors with IC50 of 4.0 and 1.0 uM, respectively.
Targets&IC50	EGFR:4.0μM, CDK2:1.0 μM

Synonyms	Janex 3
Molecular Weight	297.31
Formula	C16H15N3O3
CAS No.	211555-08-7

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 45 mg/mL (151.36 mM)

References and Literature

1. An R, et al. Pharm Res. 2009 Feb;26(2):449-58.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Cancer Active Compound Library Tyrosine Kinase Inhibitor Library Kinase Inhibitor Library Inhibitor Library Bioactive Compounds Library Max Angiogenesis related Compound Library Preclinical Compound Library Immunology/Inflammation Compound Library Cytokine Inhibitor Library Anti-Prostate Cancer Compound Library

Related Products

Related compounds with same targets

EAI001 Ligustroside (±)-Norcantharidin CGP77675 JCN037 Nezutatug Sunvozertinib EGFR-IN-3

Dose Conversion

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Calculation results:

Working concentration: mg/ml;

Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

Note:

Be sure to add the solvent(s) in order. Physical methods such as vortex, ultrasound or hot water bath can be used to aid dissolving.

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What is the mass of compound required to make a 10 mM stock solution in 10 ml of water given that the molecular weight of the compound is 197.13 g/mol?
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The answer of 19.713 mg appears in the Mass box

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An example of a dilution calculation using the Tocris dilution calculator
What volume of a given 10 mM stock solution is required to make 20ml of a 50 μM solution?
Using the equation C1V1 = C2V2, where C1=10 mM, C2=50 μM, V2=20 ml and V1 is the unknown:
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Tech Support

Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

WHI-P180 211555-08-7 Angiogenesis Apoptosis Cell Cycle/Checkpoint JAK/STAT signaling Tyrosine Kinase/Adaptors c-RET CDK EGFR VEGFR HER1 Janex3 WHI P180 RET WHI-P 180 WHI-P-180 Vascular endothelial growth factor receptor Inhibitor Janex-3 WHIP180 inhibit Janex 3 ErbB-1 Epidermal growth factor receptor inhibitor

Products are chemical reagents for research use only and are not intended for human use. We do not sell to patients.