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YM-46303

YM-46303
YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
Catalog No. T13370Cas No. 171722-81-9
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Purity:100%
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YM-46303

Purity: 100%
Catalog No. T13370Cas No. 171722-81-9

YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
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Pack SizePriceAvailabilityQuantity
1 mg$7006-8 weeks
5 mg$1,8006-8 weeks
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Product Introduction

Bioactivity
Description
YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.
In vivo
YM-46303, when compared to oxybutynin, exhibits approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, along with about a 5-fold greater selectivity for urinary bladder contraction over salivary secretion in rats. Evaluation of antimuscarinic effects on bradycardia and pressor responses in pithed rats, as well as on tremor in mice, reveals that YM-46303 could be valuable for treating urinary urge incontinence. It functions as a bladder-selective M3 antagonist with potent activities and fewer side effects[1]. In vivo, YM-46303 demonstrates selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. Additionally, it shows potent activity in a guinea pig model of methacholine-induced bronchospasm upon intravenous administration[1].
Chemical Properties
Molecular Weight358.86
FormulaC20H23ClN2O2
Cas No.171722-81-9
Storage & Solubility Information
Storagestore at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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