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YM-46303

Catalog No. T13370 CAS 171722-81-9

YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.

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YM-46303, CAS 171722-81-9

Pack Size	Availability	Price/USD	Quantity
1 mg	In stock	$ 700.00
5 mg	In stock	$ 1,800.00

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Purity: 100%

Biological Description

Chemical Properties

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Description

YM-46303 is a selective and potent muscarinic receptor antagonist that exhibits high affinity for the M3 receptor.YM-46303 can be used to study bradycardia in medullary rats.

In vivo

YM-46303, when compared to oxybutynin, exhibits approximately ten times higher inhibitory activity on bladder pressure in reflexly-evoked rhythmic contraction, along with about a 5-fold greater selectivity for urinary bladder contraction over salivary secretion in rats. Evaluation of antimuscarinic effects on bradycardia and pressor responses in pithed rats, as well as on tremor in mice, reveals that YM-46303 could be valuable for treating urinary urge incontinence. It functions as a bladder-selective M3 antagonist with potent activities and fewer side effects[1]. In vivo, YM-46303 demonstrates selective inhibitory activities on bladder pressure in reflexly-evoked rhythmic contraction against oxotremorine-induced salivary secretion. Additionally, it shows potent activity in a guinea pig model of methacholine-induced bronchospasm upon intravenous administration[1].

Molecular Weight	358.86
Formula	C20H23ClN2O2
CAS No.	171722-81-9

Storage

store at low temperature

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

References and Literature

1. Nagashima S, et al. Novel quinuclidinyl heteroarylcarbamate derivatives as muscarinic receptor antagonists. Bioorg Med Chem. 2014 Jul 1;22(13):3478-87. 2. Naito R, et al. Selective muscarinic antagonists. II. Synthesis and antimuscarinic properties of biphenylylcarbamate derivatives. Chem Pharm Bull (Tokyo). 1998 Aug;46(8):1286-94.

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Keywords

YM-46303 171722-81-9 Neuroscience AChR YM46303 YM 46303 inhibitor inhibit

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