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Zeylenone
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Catalog No. TN2328Cas No. 193410-84-3
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signalling pathways.
Zeylenone
😃Good
Catalog No. TN2328Cas No. 193410-84-3
Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signalling pathways.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 5 mg | $598 | Backorder | |
| 1 mL x 10 mM (in DMSO) | $928 | Backorder |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Zeylenone, a cyclohexene oxide from Uvaria grandiflora, has antitumour and antiproliferative activity, inhibiting cervical cancer cell proliferation and inducing apoptosis through the PI3K/AKT/mTOR and MAPK/ERK signalling pathways. |
| In vitro | Zeylenone (zey), a cyclohexene oxide compound, exerted an obvious inhibitory effect on several cancer cell lines and exhibited little cytotoxicity towards normal cells, enabling zey to play a unique role in combination therapy.we found that zey potentiated the anti-osteosarcoma efficacy of cisplatin and exhibited synergistic interactions with cisplatin in vitro, which also were confirmed in vivo by using xenograft model[1]. |
| Molecular Weight | 382.36 |
| Formula | C21H18O7 |
| Cas No. | 193410-84-3 |
| Smiles | O[C@H]1[C@H](OC(=O)c2ccccc2)C=CC(=O)[C@]1(O)COC(=O)c1ccccc1 |
| Relative Density. | 1.41 g/cm3 |
Storage & Solubility Information
| Storage | keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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