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A2A receptor antagonist 1

Catalog No. T37792 CAS 443103-97-7

Synonyms: CPI-444 analog

A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.

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A2A receptor antagonist 1, CAS 443103-97-7

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Purity: 98%

Biological Description

Chemical Properties

Storage & Solubility Information

Description	A2A receptor antagonist 1 is an antagonist of both adenosine A2A receptor and A1 receptor with Kis of 4 and 264 nM, respectively.
Targets&IC50	adenosine A2Areceptor:4 nM (Ki), A1receptor:264 nM (Ki)
In vitro	A2A receptor anyagonist 1 is a potent adenosine A2A receptor antagonist, selective over the A1 receptor and demonstrate its binding activity with Ki values of 4 and 264 nM, respectively. [1]

Synonyms	CPI-444 analog
Molecular Weight	309.3
Formula	C16H12FN5O
CAS No.	443103-97-7

Storage

Powder: -20°C for 3 years

In solvent: -80°C for 2 years

Solubility Information

DMSO: 20 mg/mL (64.66 mM), Need ultrasonic

( < 1 mg/ml refers to the product slightly soluble or insoluble )

References and Literature

1. Gillespie RJ, et al. Antagonists of the human adenosine A2A receptor. Part 3: Design and synthesis of pyrazolo[3,4-d]pyrimidines, pyrrolo[2,3-d]pyrimidines and 6-arylpurines. Bioorg Med Chem Lett. 2008 May 1;18(9):2924-9.

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Keywords

A2A receptor antagonist 1 443103-97-7 GPCR/G Protein Neuroscience Adenosine Receptor CPI444 CPI 444 disease Parkinson CPI-444 analog Inhibitor CPI-444 hypolocomotion inhibit model P1 receptor inhibitor

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