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BMS-986176

Catalog No. T35856 CAS 1815613-42-3

AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).

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BMS-986176, CAS 1815613-42-3

Pack Size	Availability	Price/USD
1 mg	In stock	$ 175.00
5 mg	In stock	$ 372.00
10 mg	In stock	$ 556.00
25 mg	In stock	$ 896.00
50 mg	In stock	$ 1,220.00
100 mg	In stock	$ 1,650.00
500 mg	In stock	$ 3,290.00
1 mL * 10 mM (in DMSO)	In stock	$ 397.00

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Biological Description

Chemical Properties

Storage & Solubility Information

Description	AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
Targets&IC50	AAK1:2.2 nM
In vitro	AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis[1].

Molecular Weight	385.4
Formula	C19H23F4N3O
CAS No.	1815613-42-3

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 220 mg/mL (570.84 mM), Sonication is recommended.

References and Literature

1. Guanglin Luo, et al. Discovery of ( S)-1-((2',6-Bis(difluoromethyl)-[2,4'-bipyridin]-5-yl)oxy)-2,4-dimethylpentan-2-amine (BMS-986176/LX-9211): A Highly Selective, CNS Penetrable, and Orally Active Adaptor Protein-2 Associated Kinase 1 Inhibitor in Clinical Trials for the Treatment of Neuropathic Pain. J Med Chem. 2022 Mar 24;65(6):4457-4480. 2. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.

Related compound libraries

This product is contained In the following compound libraries：

Anti-Neurodegenerative Disease Compound Library Drug Repurposing Compound Library Inhibitor Library Kinase Inhibitor Library Clinical Compound Library Neuronal Signaling Compound Library Bioactive Compound Library Bioactive Compounds Library Max

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(Iso)-BMT-124110 Formate LP-922761 SM1-71 BMT-124110 Formate BMT-124110 RSS0680 SGC-AAK1-1 LP-935509

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Method for preparing DMSO master liquid: mg drug pre-dissolved in μL DMSO (Master liquid concentration mg/mL)，Please contact us first if the concentration exceeds the DMSO solubility of the batch of drug.

Method for preparing in vivo formulation：Take μL DMSO master liquid, next add μL PEG300， mix and clarify, next add μL Tween 80，mix and clarify, next add μL ddH₂O, mix and clarify.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc.

Keywords

BMS-986176 1815613-42-3 Neuroscience AAK1 (AP2 associated kinase 1) BMS986176 Inhibitor LX9211 AAK-1-IN-1 BMS 986176 AAK1 LX-9211 inhibit neurodegenerative LX 9211 inhibitor

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