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BMS-986176

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COA HNMR HPLC

BMS-986176

Catalog No. T35856Cas No. 1815613-42-3

AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).

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Pack Size	Price	Availability
1 mg	$175	In Stock
5 mg	$372	In Stock
10 mg	$556	In Stock
25 mg	$896	In Stock
50 mg	$1,220	In Stock
100 mg	$1,650	In Stock
500 mg	$3,290	In Stock
1 mL x 10 mM (in DMSO)	$397	In Stock

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Product Introduction

Bioactivity

Description

AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1].
Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis[1].
[1]. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1.

In vitro

AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis[1].

Chemical Properties

Molecular Weight	385.4
Formula	C19H23F4N3O
Cas No.	1815613-42-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 220 mg/mL (570.84 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	2.5947 mL	12.9735 mL	25.9471 mL	129.7353 mL
5 mM	0.5189 mL	2.5947 mL	5.1894 mL	25.9471 mL
10 mM	0.2595 mL	1.2974 mL	2.5947 mL	12.9735 mL
20 mM	0.1297 mL	0.6487 mL	1.2974 mL	6.4868 mL
50 mM	0.0519 mL	0.2595 mL	0.5189 mL	2.5947 mL
100 mM	0.0259 mL	0.1297 mL	0.2595 mL	1.2974 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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Tech Support

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