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BMS-986176
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Catalog No. T35856Cas No. 1815613-42-3
Alias LX-9211
AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
BMS-986176
🥰Excellent
Purity: 98.6%
Catalog No. T35856Alias LX-9211Cas No. 1815613-42-3
AAK1-IN-1 is a highly selective and potent inhibitor of adaptor associated kinase 1 (AAK1, IC50 = 2 nM).
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $175 | In Stock | |
| 5 mg | $372 | In Stock | |
| 10 mg | $556 | In Stock | |
| 25 mg | $896 | In Stock | |
| 50 mg | $1,220 | In Stock | |
| 100 mg | $1,650 | In Stock | |
| 500 mg | $6,339 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $397 | In Stock |
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Purity:98.6%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AAK1-IN-1 (example 123) is an AAK1 (adaptor associated kinase 1) inhibitor with an IC50 of 2.2 nM. AAK1-IN-1 can be used for neurodegenerative diseases research[1]. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases. AAKl mRNA exists in two splice forms termed short and long. The long form predominates and is highly expressed in brain and heart. AAKl is enriched in synaptosomal preparations and is co-localized with endocytic structures in cultured cells. AAKl modulates clatherin coated endocytosis, a process that is important in synaptic vesicle recycling and receptor-mediated endocytosis[1]. [1]. Guanglin Luo, et al. Biaryl kinase inhibitors. WO2015153720A1. |
| Targets&IC50 | AAK1:2.2 nM |
| In vitro | AAK1-IN-1can be used for neurodegenerative disease studies. Adaptor associated kinase 1 (AAK1) is a member of the Arkl/Prkl family of serine/threonine kinases and modulates clatherin coated endocytosis. and receptor-mediated endocytosis[1]. |
| Alias | LX-9211 |
| Molecular Weight | 385.4 |
| Formula | C19H23F4N3O |
| Cas No. | 1815613-42-3 |
| Smiles | CC(C)C[C@](C)(N)COc1ccc(nc1C(F)F)-c1ccnc(c1)C(F)F |
| Relative Density. | 1.188 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 220 mg/mL (570.84 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
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Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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