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Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $44 | In Stock | |
5 mg | $96 | In Stock | |
10 mg | $165 | In Stock | |
25 mg | $319 | In Stock | |
50 mg | $479 | In Stock | |
100 mg | $686 | In Stock | |
1 mL x 10 mM (in DMSO) | $83 | In Stock |
Description | Alliin ((S)-3-(Allylsulphinyl)-L-alanine) is a garlic organosulfur compound that possesses various pharmacological properties.alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. Alliin might be used as an anti-inflammatory agent in the treatment of ALI. |
In vivo | LPS-induced ALI was induced in BALB/c mice by intranasal instillation of LPS.?Alliin was administered intraperitoneally to mice 1 h after LPS treatment.?Alliin markedly inhibited lung myeloperoxidase (MPO) activity and wet/dry (W/D) ratio induced by LPS.?Alliin also inhibited TNF-α and IL-1β in the bronchoalveolar lavage fluid (BALF) induced by LPS.?Furthermore, LPS-induced lung pathological injury was attenuated by treatment of alliin.?LPS-induced NF-κB activation was significantly inhibited by alliin.?In addition, the expression of peroxisome proliferator-activated receptor γ (PPARγ) was up-regulated by treatment of alliin.?Taken together,Alliin protected against LPS-induced ALI by activating PPARγ, which subsequently inhibited LPS-induced NF-κB activation and inflammatory response. |
Alias | (S)-3-(Allylsulphinyl)-L-alanine |
Molecular Weight | 177.22 |
Formula | C6H11NO3S |
Cas No. | 556-27-4 |
Smiles | N[C@@H](CS(=O)CC=C)C(O)=O |
Relative Density. | 1.354g/cm3 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||
Solubility Information | DMSO: 3 mg/mL (16.92 mM) | ||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||
DMSO
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