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AMG-009
🥰Excellent
Catalog No. T14211Cas No. 1027847-67-1
AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.
AMG-009
🥰Excellent
Purity: 97.88%
Catalog No. T14211Cas No. 1027847-67-1
AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $41 | In Stock | |
| 5 mg | $92 | In Stock | |
| 10 mg | $133 | In Stock | |
| 25 mg | $223 | In Stock | |
| 50 mg | $392 | In Stock | |
| 100 mg | $668 | In Stock |
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Purity:97.88%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | AMG-009 is a selective and potent dual antagonist of CRTH2 and DP, with an IC50 value of 3 nM for CRTH2 and 12 nM for DP receptors. |
| Targets&IC50 | CRTH2/DP2 Receptor:3 nM |
| In vitro | AMG-009 inhibits PGD2-induced down-modulation of CRTH2 on CD16 negative eosinophils in human whole blood with a Ki of 1 nM[1]. |
| In vivo | AMG 009 (3, 10, or 30 mg/kg, s.c.) dose-dependently decreases PGD2 aerosol-induced airway resistance and significantly enhances DP potency (Kb of 82 nM) in an acute guinea pig model[1][2]. |
| Molecular Weight | 581.47 |
| Formula | C26H26Cl2N2O7S |
| Cas No. | 1027847-67-1 |
| Smiles | O=C(O)CC1=CC=C(OC2=CC=C(C=C2NS(=O)(=O)C3=CC=C(Cl)C=C3Cl)C(=O)NCCCC)C(OC)=C1 |
| Relative Density. | 1.403 g/cm3 (Predicted) |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 100 mg/mL (171.98 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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