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Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | $15 | In Stock | |
25 mg | $40 | In Stock | |
50 mg | $55 | In Stock | |
100 mg | $78 | In Stock | |
500 mg | $183 | In Stock |
Description | Amiloride hydrochloride (Amiloride HCl) is an effective sodium channel blocker of epithelial. |
Targets&IC50 | uPA:7 μM(Ki) |
In vitro | In salt-sensitive hypertensive animals, Amiloride antagonizes or blocks the action of aldosterone in cells, as well as within vascular and renal tissues. Daily subcutaneous injections of 1 mg/kg Amiloride in DOCA-salt hypertensive rats reversed the initial increase in collagen deposition. In stroke-prone spontaneously hypertensive rats, Amiloride administration via saline drinking water delayed the onset of proteinuria and improved histological scores in brain and kidney tissues compared to controls. |
In vivo | Upon increased perfusion pressure, 1 μM Amiloride and 30 nM Benzamil inhibit myogenic responses by blocking the activity of ENaC proteins, thereby suppressing vasoconstriction. In vascular smooth muscle cells, Amiloride completely inhibits sodium influx. Amiloride is a relatively selective inhibitor of epithelial sodium channels (ENaC) with an IC 50 of 0.1 μM to 0.5 μM. Although less effective as a Na+/H+ exchanger (NHE) inhibitor, Amiloride's IC 50 values range from as low as 3 μM at low external sodium concentrations to 1 mM at high external sodium concentrations. Furthermore, Amiloride exerts a weak inhibitory effect on Na+/Ca2+ exchange (NCX) with an IC 50 of 1 mM. |
Alias | Amiloride HCl, MK-870 hydrochloride |
Molecular Weight | 266.09 |
Formula | C6H9Cl2N7O |
Cas No. | 2016-88-8 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 26.6mg/ mL (100 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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