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Amiloride hydrochloride dihydrate
Catalog No. T0175LCas No. 17440-83-4
Alias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrate
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
Amiloride hydrochloride dihydrate
Catalog No. T0175LAlias MK-870 hydrochloride dihydrate, Amiloride HCl dihydrateCas No. 17440-83-4
Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss.
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Purity:100%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Amiloride hydrochloride dihydrate (Amiloride HCl dihydrate) is a pyrazine compound inhibiting SODIUM reabsorption through SODIUM CHANNELS in renal EPITHELIAL CELLS. This inhibition creates a negative potential in the luminal membranes of principal cells, located in the distal convoluted tubule and collecting duct. Negative potential reduces secretion of potassium and hydrogen ions. Amiloride hydrochloride dihydrate is used in conjunction with DIURETICS to spare POTASSIUM loss. |
| In vivo | Amiloride inhibits autophosphorylation of the EGF receptor and induces dephosphorylation of phosphoinositide 3-kinase, phosphoinositide-dependent kinase-1, PTEN (phosphatase and tensin homolog deleted on chromosome ten), and PP1 alpha phosphatase. It also blocks the adhesion of HL-60 cells induced by phorbol ester (where adhesion indicates a differentiated state), unlike dimethylamiloride (and EIPA, another Amiloride-like effective drug). In intact rabbit proximal tubules, Amiloride reduces oxygen consumption sensitive to ouabain in the presence of extracellular sodium at varying concentrations. |
| Alias | MK-870 hydrochloride dihydrate, Amiloride HCl dihydrate |
| Molecular Weight | 302.12 |
| Formula | C6H8ClN7O·HCl·2H2O |
| Cas No. | 17440-83-4 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | Ethanol: < 1 mg/mL (insoluble or slightly soluble) H2O: 17 mg/mL (56.3 mM) DMSO: 25 mg/mL (82.7 mM) | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
H2O/DMSO
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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Keywords
Sodium ChannelTransient receptor potential channelsApoptosisNa channelsMK 870 HydrochlorideNa+ channelsMK-870 HydrochlorideMK-870 hydrochloride DihydrateAmiloride HydrochlorideAmiloride HCl DihydrateinhibitTRP ChannelInhibitorAmiloride HClAmiloride hydrochloride DihydrateAmiloride hydrochloride dihydrateMK870 Hydrochloride
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