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ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
1 mg | 51 € | In Stock | |
5 mg | 112 € | In Stock | |
10 mg | 169 € | In Stock | |
25 mg | 303 € | In Stock | |
50 mg | 437 € | In Stock | |
100 mg | 615 € | In Stock | |
200 mg | 829 € | In Stock | |
1 mL x 10 mM (in DMSO) | 144 € | In Stock |
Description | ARRY 520 hydrochloride is a kinesin spindle protein (KSP) inhibitor.ARRY 520 hydrochloride induces cell death by apoptosis and has potent anti-proliferative activity. |
In vitro | ARRY 520 causes accumulation of cells in the G2/M phase of the cell cycle in a dose-dependent manner in HeLa cells[1]. ARRY 520 induces mitotic arrest in multiple cell lines and exhibits anti-proliferative against a broad range of human and rodent tumor cell lines, including a variety of leukemias and solid tumors[1].ARRY 520 induces apoptosis in a dose-dependent manner in HeLa cells[1]. ARRY 520 potently induces cell cycle block and subsequent death in leukemic cells via the mitochondrial pathway and has potential to eradicate AML progenitor cells[2]. ARRY 520 is able to induce caspase-2 activation[3]. ARRY 520 is cytotoxic in Type II EOC cells[3]. |
In vivo | ARRY 520 has anti-tumor activitiy in vivo. ARRY 520 induced a decrease in tumor kinetics in a dose-dependent manner in female nude mice, EOC mice xenograft model[3]. |
Molecular Weight | 456.94 |
Formula | C20H23ClF2N4O2S |
Cas No. | 1385020-40-5 |
Smiles | O=C(N1[C@@](C2=CC=CC=C2)(CCCN)SC(C3=CC(F)=CC=C3F)=N1)N(OC)C.[H]Cl |
Relative Density. | no data available |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
Solubility Information | DMSO: 50 mg/mL (109.42 mM) | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
DMSO
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