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ATP disodium trihydrate

ATP disodium trihydrate
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) is an important substance for energy storage and metabolism in the body. It is an important endogenous signaling molecule in immunity and inflammation, which provides energy for the body's metabolism and also acts as a coenzyme in cells.
Catalog No. T64980Cas No. 51963-61-2
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ATP disodium trihydrate

Catalog No. T64980Cas No. 51963-61-2
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) is an important substance for energy storage and metabolism in the body. It is an important endogenous signaling molecule in immunity and inflammation, which provides energy for the body's metabolism and also acts as a coenzyme in cells.
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Product Introduction

Bioactivity
Description
ATP disodium trihydrate (Adenosine-5'-triphosphate disodium trihydrate) is an important substance for energy storage and metabolism in the body. It is an important endogenous signaling molecule in immunity and inflammation, which provides energy for the body's metabolism and also acts as a coenzyme in cells.
In vitro
ATP disodium trihydrate (5 mM; 1 h) with LPS (1 μg/mL) has a synergistic effect on the activation of the NLRP3 inflammasome in HGFs.[3]
ATP disodium trihydrate (2 mM; 0.5-24 h) induces BMDM to secrete IL-1β, KC and MIP-2 in a caspase-1 activation-dependent manner.[4]
ATP disodium trihydrate promotes neutrophil chemotaxis.[4]
In vivo
ATP disodium trihydrate (50 mg/kg; ip) protects mice against bacterial infection and induces the secretion of IL-1β, KC, and MIP-2, promoting neutrophil recruitment.[4]
AliasAdenosine-5'-triphosphate disodium trihydrate
Chemical Properties
Molecular Weight605.19
FormulaC10H20N5Na2O16P3
Cas No.51963-61-2
Storage & Solubility Information
StorageShipping with blue ice.
Solubility Information
DMSO: 0.9 mg/mL (1.5 mM), Sonication and heating to 80℃ are recommended.
H2O: 225.0 mg/mL (371.8 mM), Sonication is recommended.
Solution Preparation Table
DMSO/H2O
1mg5mg10mg50mg
1 mM1.6524 mL8.2619 mL16.5237 mL82.6187 mL
H2O
1mg5mg10mg50mg
5 mM0.3305 mL1.6524 mL3.3047 mL16.5237 mL
10 mM0.1652 mL0.8262 mL1.6524 mL8.2619 mL
20 mM0.0826 mL0.4131 mL0.8262 mL4.1309 mL
50 mM0.0330 mL0.1652 mL0.3305 mL1.6524 mL
100 mM0.0165 mL0.0826 mL0.1652 mL0.8262 mL

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Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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