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AZ13705339

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Purity:98.57%

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COA HPLC HNMR

AZ13705339

Catalog No. T26704Cas No. 2016806-57-6

AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.

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Pack Size	Price	Availability
2 mg	$39	In Stock
5 mg	$64	In Stock
10 mg	$98	In Stock
25 mg	$222	In Stock
50 mg	$355	In Stock
100 mg	$572	In Stock

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Product Introduction

Bioactivity

Description	AZ13705339 is an effective inhibitor of PAK1 with an IC50 of 0.33 nM and a Kd of 0.28 nM. AZ13705339 binds PAK2 with a Kd of 0.32 nM. AZ13705339 can be used in studies about cancers.
In vitro	AZ13705339 (300 nM) prevents Siglec-8 binding-induced eosinophil death[2]. In Namalwa cells, AZ13705339 (1 μM) inhibits αIgM-controlled but not PMA-induced adhesion[3].
In vivo	In rats, AZ13705339 (100 mg/kg, p.o.) exhibits moderate clearance and Cmax of 7.7 μM[1].
Alias	AZ-13705339, AZ 13705339

Chemical Properties

Molecular Weight	629.75
Formula	C33H36FN7O3S
Cas No.	2016806-57-6

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year

Solubility Information

DMSO: 225 mg/mL (357.3 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5879 mL	7.9397 mL	15.8793 mL	79.3966 mL
5 mM	0.3176 mL	1.5879 mL	3.1759 mL	15.8793 mL
10 mM	0.1588 mL	0.7940 mL	1.5879 mL	7.9397 mL
20 mM	0.0794 mL	0.3970 mL	0.7940 mL	3.9698 mL
50 mM	0.0318 mL	0.1588 mL	0.3176 mL	1.5879 mL
100 mM	0.0159 mL	0.0794 mL	0.1588 mL	0.7940 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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