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BIM-46174 is a 5,6,7,8-tetrahydroimidazole [1,2-a] pyrazine derivative that inhibits the heterotrimeric Galpha/Gbetagamma protein complex and has anticancer activity, inhibiting the growth of a large number of human cancer cell lines, inducing caspase-3-dependent cancer cell apoptosis, and inducing poly (ADP-ribose) polymerase cleavage.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
25 mg | $1,520 | 6-8 weeks | |
50 mg | $1,980 | 6-8 weeks | |
100 mg | $2,500 | 6-8 weeks |
Description | BIM-46174 is a 5,6,7,8-tetrahydroimidazole [1,2-a] pyrazine derivative that inhibits the heterotrimeric Galpha/Gbetagamma protein complex and has anticancer activity, inhibiting the growth of a large number of human cancer cell lines, inducing caspase-3-dependent cancer cell apoptosis, and inducing poly (ADP-ribose) polymerase cleavage. |
In vitro | METHODS: RAW-blue macrophages were pretreated with BIM-46174 (20 μM, 30 min) and then treated with 10 μg/mL imiquimod. Cell lysates from WT and KD cells were separated by SDS-PAGE, and the blots were probed with a phosphorylation-specific polyclonal rabbit antibody against NF-κBp65-Ser (P). RESULTS:BIM-46174 significantly blocked nucleic acid-induced TLR-7 and -9 MyD88 recruitment, NF-κB activation, and proinflammatory TNFα and MCP-1 cytokine responses. [3] |
Alias | BIM46174, BIM 46174 |
Molecular Weight | 398.57 |
Formula | C22H30N4OS |
Cas No. | 195450-11-4 |
Storage | keep away from moisture | Shipping with blue ice. |
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