BMS-1166

BMS-1166 is a potent inhibitor of the PD-1/PD-L1 interaction.

Catalog No. T5697Cas No. 1818314-88-3

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Purity:99.22%

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BMS-1166

Catalog No. T5697Cas No. 1818314-88-3

BMS-1166 is a potent inhibitor of the PD-1/PD-L1 interaction.

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Pack Size	Price	Availability
1 mg	$89	In Stock
2 mg	$125	In Stock
5 mg	$190	In Stock
10 mg	$312	In Stock
25 mg	$579	In Stock
50 mg	$829	In Stock
100 mg	$1,150	In Stock
1 mL x 10 mM (in DMSO)	$273	In Stock

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Product Introduction

Bioactivity

Description	BMS-1166 is a potent inhibitor of the PD-1/PD-L1 interaction.
Targets&IC50	PD-1/PD-L1:1.4 nM
In vitro	BMS-1166 alleviate the inhibitory effect of the soluble PD-L1 on the T-cell receptor-mediated activation of T-lymphocytes. Moreover, the compounds were effective in attenuating the inhibitory effect of the cell surface-associated PD-L1.
Kinase Assay	Purified proteins in 10 mM Tris (pH 8.0) containing 20 mM NaCl, were concentrated to 5 mg/ml, mixed with the inhibitor in 1:3 molar ratio (protein:compound) and clarified by centrifugation at 15 000 × g for 10 min. Supernatant was used for screening using a sitting-drop vapor diffusion method. Diffraction-quality crystals were obtained at room temperature from 0.1 M Tris pH 8.5 containing 0.2 M magnesium chloride and 30% (w/v) PEG 4000 for the hPD-L1/BMS-1001 complex and from 0.01 M Tris pH 8.4 containing 0.28 M sodium chloride and 27% (w/v) PEG 4000 for hPD-L1/BMS-1166 complex.

Chemical Properties

Molecular Weight	641.11
Formula	C₃₆H₃₃ClN₂O₇
Cas No.	1818314-88-3

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

DMSO: 125 mg/mL (194.97 mM)

Solution Preparation Table

DMSO

	1mg	5mg	10mg	50mg
1 mM	1.5598 mL	7.7990 mL	15.5979 mL	77.9897 mL
5 mM	0.3120 mL	1.5598 mL	3.1196 mL	15.5979 mL
10 mM	0.1560 mL	0.7799 mL	1.5598 mL	7.7990 mL
20 mM	0.0780 mL	0.3899 mL	0.7799 mL	3.8995 mL
50 mM	0.0312 mL	0.1560 mL	0.3120 mL	1.5598 mL
100 mM	0.0156 mL	0.0780 mL	0.1560 mL	0.7799 mL

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In Vivo Formulation Calculator (Clear solution)

Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:

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A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent

DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

For Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.

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Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc