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CCB02

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TargetMol
Catalog No. T10704Cas No. 2100864-57-9

CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.

CCB02

CCB02

🥰Excellent
TargetMol
Purity: 99.51%
Catalog No. T10704Cas No. 2100864-57-9
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
Pack SizePriceAvailabilityQuantity
1 mg$117In Stock
5 mg$289In Stock
10 mg$455In Stock
25 mg$889In Stock
50 mg$1,360In Stock
100 mg$1,860In Stock
1 mL x 10 mM (in DMSO)$318In Stock
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Purity:99.51%
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Product Introduction

Bioactivity
Description
CCB02 is a selective CPAP-tubulin interaction inhibitor (IC50: 689 nM) with anti-tumor activity, showing no inhibition on cell cycle- and centrosome-related kinases, nor affecting the phosphorylation status of Aurora-A, CDK2, Plk1, Plk2, and CHK1.
Targets&IC50
CPAP-tubulin:689 nM
In vitro
CCB02 perturbs CPAP PN2-3-tubulin interaction with an IC50 of 0.441 μM in a PN2-3 CPAP-GST pull-down assay. In concentrations ranging from 0.1 to 15 μM over 72 hours, CCB02 inhibits the proliferation of cancer cells with extra centrosomes (IC50s: 0.86-2.9 μM). Additionally, CCB02 activates the spindle assembly checkpoint, induces PCM proteins recruitment to centrosomes, and enhances the microtubule nucleation activities of centrosomes[1].
In vivo
CCB02 (30 mg/kg, p.o. daily for 24 days) exhibits a potent anti-tumor effect in nude mice with subcutaneous human lung (H1975 T790M cells) tumor xenografts, suppresses MDA-MB-231 cell migration, and induces multipolar mitosis in mouse xenografts[1].
Chemical Properties
Molecular Weight235.24
FormulaC14H9N3O
Cas No.2100864-57-9
SmilesCOc1ncc2cc3ccccc3nc2c1C#N
Relative Density.1.33 g/cm3 (Predicted)
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 22.5 mg/mL (95.6 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM4.2510 mL21.2549 mL42.5098 mL212.5489 mL
5 mM0.8502 mL4.2510 mL8.5020 mL42.5098 mL
10 mM0.4251 mL2.1255 mL4.2510 mL21.2549 mL
20 mM0.2125 mL1.0627 mL2.1255 mL10.6274 mL
50 mM0.0850 mL0.4251 mL0.8502 mL4.2510 mL

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