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ccc_R08

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Catalog No. T73440Cas No. 2919019-72-8

ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).

ccc_R08

ccc_R08

🥰Excellent
Purity: 99.69%
Catalog No. T73440Cas No. 2919019-72-8
ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).
Pack SizePriceAvailabilityQuantity
1 mg$159In Stock
5 mg$355In Stock
10 mg$533In Stock
25 mg$1,120In Stock
50 mg$1,490In Stock
100 mg$1,980In Stock
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Purity:99.69%
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Product Introduction

Bioactivity
Description
ccc_R08 is an orally available HBV cccDNA inhibitor that reduces extracellular levels of HBV DNA, HBsAg, and HBeAg in a dose-dependent manner. ccc_R08 is investigational for use in the treatment of HBV infections. ccc_R08 has been shown to be effective in the treatment of hepatitis C virus (HCV).
In vitro
In HepDES19 cells, ccc_R08 (0.3, 1.0, 3.2, 10, 32 µM; 5 days) reduced the levels of cccDNA, protein-free RC-DNA, and double-stranded linear DNA (DL-DNA)[1].
In vivo
In the HBV circle mouse model, ccc_R08 (20 mg/kg; oral administration; twice daily for 2 weeks) led to the clearance of cccDNA from the livers of HBV circle mice[1].
Chemical Properties
Molecular Weight414.84
FormulaC22H19ClO6
Cas No.2919019-72-8
SmilesO=C(O)C1CC(OCCOC=2C=CC(=CC2)C=3OC=4C(Cl)=CC=CC4C(=O)C3)C1
Relative Density.no data available
Storage & Solubility Information
Storagekeep away from direct sunlight,keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.
Solubility Information
DMSO: 80 mg/mL (192.85 mM), Sonication is recommended.
Solution Preparation Table
DMSO
1mg5mg10mg50mg
1 mM2.4106 mL12.0528 mL24.1057 mL120.5284 mL
5 mM0.4821 mL2.4106 mL4.8211 mL24.1057 mL
10 mM0.2411 mL1.2053 mL2.4106 mL12.0528 mL
20 mM0.1205 mL0.6026 mL1.2053 mL6.0264 mL
50 mM0.0482 mL0.2411 mL0.4821 mL2.4106 mL
100 mM0.0241 mL0.1205 mL0.2411 mL1.2053 mL

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TargetMol | Animal experimentsFor example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . TargetMol | Animal experiments A total of 10 animals were administered, and the formula you used is 5% TargetMol | reagent DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。
Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSOTargetMol | reagent (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
Preparation method for in vivo formula: Take 50 μL DMSOTargetMol | reagent main solution, add 300 μLPEG300TargetMol | reagent mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2OTargetMol | reagent mix well and clarify
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