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Cimetropium Bromide

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Cimetropium Bromide

Catalog No. T14966Cas No. 51598-60-8

Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.

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Pack Size	Price	Availability
2 mg	$140	5 days
25 mg	$766	6-8 weeks
50 mg	$996	6-8 weeks
100 mg	$1,540	6-8 weeks

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Product Introduction

Bioactivity

Description	Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
In vitro	Cimetropium reduces the release of labeled acetylcholine (ACh) elicited by electrical field stimulation, particularly when muscarinic autoinhibition is blocked, as observed in superfusion experiments using preparations preloaded with labeled choline [2]. Furthermore, it exhibits a powerful antimuscarinic action by inhibiting the contraction of longitudinal muscle preparations. As a competitive antagonist, Cimetropium Bromide effectively counteracts muscarinic-mediated contractions in isolated colonic preparations from various species, demonstrating affinity values (pA2) between 7.41 and 7.82 [1].
In vivo	Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1].
Alias	DA-3177

Chemical Properties

Molecular Weight	438.36
Formula	C21H28BrNO4
Cas No.	51598-60-8

Storage & Solubility Information

Storage

Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

Solubility Information

H2O: 50 mg/mL (114.06 mM), Sonication is recommended.

Solution Preparation Table

H2O

	1mg	5mg	10mg	50mg
1 mM	2.2812 mL	11.4062 mL	22.8123 mL	114.0615 mL
5 mM	0.4562 mL	2.2812 mL	4.5625 mL	22.8123 mL
10 mM	0.2281 mL	1.1406 mL	2.2812 mL	11.4062 mL
20 mM	0.1141 mL	0.5703 mL	1.1406 mL	5.7031 mL
50 mM	0.0456 mL	0.2281 mL	0.4562 mL	2.2812 mL
100 mM	0.0228 mL	0.1141 mL	0.2281 mL	1.1406 mL

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DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。

Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO TargetMol | reagent

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Preparation method for in vivo formula: Take 50 μL DMSO TargetMol | reagent

main solution, add 300 μLPEG300 TargetMol | reagent

mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O TargetMol | reagent

mix well and clarify

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