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Cimetropium Bromide
Catalog No. T14966Cas No. 51598-60-8
Alias DA-3177
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
Cimetropium Bromide
Catalog No. T14966Alias DA-3177Cas No. 51598-60-8
Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 2 mg | $140 | 5 days | |
| 25 mg | $766 | 6-8 weeks | |
| 50 mg | $996 | 6-8 weeks | |
| 100 mg | $1,540 | 6-8 weeks |
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Product Introduction
Bioactivity
Chemical Properties
| Description | Cimetropium Bromide is a mAChR antagonist used for long-term treatment of irritable bowel syndrome. |
| In vitro | Cimetropium reduces the release of labeled acetylcholine (ACh) elicited by electrical field stimulation, particularly when muscarinic autoinhibition is blocked, as observed in superfusion experiments using preparations preloaded with labeled choline [2]. Furthermore, it exhibits a powerful antimuscarinic action by inhibiting the contraction of longitudinal muscle preparations. As a competitive antagonist, Cimetropium Bromide effectively counteracts muscarinic-mediated contractions in isolated colonic preparations from various species, demonstrating affinity values (pA2) between 7.41 and 7.82 [1]. |
| In vivo | Cimetropium Bromide (10-100 μg/kg) counteracts colonic motor response to neostigmine administration (ID50: 27.9 μg/kg); both tonic and phasic components of contractile response are affected. Cimetropium is a potent inhibitor of large bowel motility evoked by both exogenous and endogenous stimuli when administered intravenously to conscious dogs provided with a colonic Thiry fistula. In a comparable range of doses (3-100μg/kg), the drug inhibits motor activity elicited by intraluminal distension [1]. |
| Alias | DA-3177 |
| Molecular Weight | 438.36 |
| Formula | C21H28BrNO4 |
| Cas No. | 51598-60-8 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | H2O: 50 mg/mL (114.06 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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