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Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
5 mg | 1.159 € | 7-10 days |
Description | Cirsilineol (Eupatrin) is isolated from the herb of Artemisia vestita Wall and shows immunosuppressive, anti-proliferative, and anti-tumor properties. Cirsilineol selectively induces apoptosis via the mitochondrial pathway. |
In vitro | Cirsilineol (0.1, 1, 10 μM) dose-dependently inhibits single mixed lymphocyte reaction and the proliferation of Concanava A-induced T-cells in Splenocytes. Cirsilineol (1, 5, 10 μM) inhibits IFN-γ-induced Tyr701 phosphorylation of STAT1 and the activation of JAK2 in Splenic CD4+ T cells[3]. |
In vivo | In female C57BL/6, BALB/c, and DO11.10 transgenic mice with TNBS, Cirsilineol (3-30 mg/kg) reduces inflammatory infiltration, restores the destructive mucosal architecture, and remisses edema thus improving the effects on the body weights and survival rate of mice. Cirsilineol ameliorates TNBS-induced Th1-mediated colitis by inhibiting IFN-γ/STAT1/T-bet signaling in CD4+ T cells[1]. |
Alias | SPM 927, Fastigenin, Eupatrin |
Molecular Weight | 344.32 |
Formula | C18H16O7 |
Cas No. | 41365-32-6 |
Smiles | COc1cc(ccc1O)-c1cc(=O)c2c(O)c(OC)c(OC)cc2o1 |
Relative Density. | 1.387g/cm3 |
Storage | store at low temperature,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
Solubility Information | DMSO: Soluble |
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