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CP-31398

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Catalog No. T201533Cas No. 259199-65-0

CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.

CP-31398

CP-31398

😃Good
Catalog No. T201533Cas No. 259199-65-0
CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.
Pack SizePriceAvailabilityQuantity
10 mgInquiry10-14 weeks
50 mgInquiry10-14 weeks
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Product Introduction

Bioactivity
Description
CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.
In vitro
CP-31398, at a concentration of 36.75 μM for 16 hours, induces the expression of p21 in cells with mutated p53. Additionally, CP-31398 administered at 15 μg/mL for 20 hours, promotes apoptosis and arrests the cell cycle in SW480 cells.
In vivo
In a xenograft mouse model, CP-31398 (100 mg/kg, orally administered, twice daily for a duration of 7 days) demonstrated significant antitumor activity.
Chemical Properties
Molecular Weight362.47
FormulaC22H26N4O
Cas No.259199-65-0
Storage & Solubility Information
StoragePowder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice.

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