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CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties.
Pack Size | Price | Availability | Quantity |
---|---|---|---|
10 mg | Inquiry | 10-14 weeks | |
50 mg | Inquiry | 10-14 weeks |
Description | CP-31398 stabilizes the active conformation of p53 in cancer cells with either mutated or wild-type p53, enhancing its activity. Additionally, CP-31398 upregulates target genes of p53 such as p21WAF1/Cip1 and KILLER/DR5. This compound possesses tumor-suppressive properties. |
In vitro | CP-31398, at a concentration of 36.75 μM for 16 hours, induces the expression of p21 in cells with mutated p53. Additionally, CP-31398 administered at 15 μg/mL for 20 hours, promotes apoptosis and arrests the cell cycle in SW480 cells. |
In vivo | In a xenograft mouse model, CP-31398 (100 mg/kg, orally administered, twice daily for a duration of 7 days) demonstrated significant antitumor activity. |
Molecular Weight | 362.47 |
Formula | C22H26N4O |
Cas No. | 259199-65-0 |
Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. |
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