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Cronidipine
🥰Excellent
Catalog No. T27087Cas No. 113759-50-5
Alias LF-20254, LF20254, LF 20254, LF 2.0254
Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.
Cronidipine
🥰Excellent
Purity: 99.25%
Catalog No. T27087Alias LF-20254, LF20254, LF 20254, LF 2.0254Cas No. 113759-50-5
Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $146 | In Stock | |
| 5 mg | $350 | In Stock | |
| 10 mg | $530 | In Stock | |
| 25 mg | $859 | In Stock | |
| 50 mg | $1,180 | In Stock | |
| 100 mg | $1,590 | In Stock | |
| 500 mg | $3,190 | In Stock |
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Questions
QI need a total of 500 mg of the product for animal experiments, but it won't be used up all at once. How should I dissolve it?
ADetermining the amount based on solution clarity.1. If the prepared solution is clear, it can be prepared in a larger amount for one-time use and stored at 4°C. It is recommended to prepare the solution once a week, as prolonged storage may lead to loss of efficacy. 2. If the prepared solution is a suspension, it is recommended to prepare and use immediately each time.
QCan Tween-80 be used instead of Tween-20?
ATween-20 is not recommended. Tween-80 has better tolerance and has been used as a tool to assess the behavioral effects of experimental drugs and toxins without significant side effects.
Reference: Castro CA, Hogan JB, Benson KA, Shehata CW, Landauer MR. Behavioral effects of vehicles: DMSO, ethanol, Tween-20, Tween-80, and emulphor-620. Pharmacol Biochem Behav. 1995 Apr;50(4):521-6.
QHow to choose the appropriate solvent?
ACommon solvents include DMSO, water, ethanol, etc. Please select the appropriate solvent according to the solubility reference. If the inhibitor can be dissolved in DMSO, it is recommended to use freshly opened DMSO without moisture absorption. If the inhibitor can be dissolved in water, solvents like sterile water, physiological saline, sterile PBS ahd culture medium are recommended.
QWhat is the calculation method for preparing a solution?
AThe calculation method is as follows:
（1） c=n/v=m/M/v
Concentration=amount of substance/volume=mass/molar mass/volume
(2) The solution preparation table is presented in the the product details page on our website. You can add the volume of solvent as referenced.
QIf the product does not dissolve even when it is below the maximum solubility stated in the instructions, what should I do?
AIt is recommended to utilize some auxiliary dissolution methods, such as heating to 45°C or using sonication to accelerate dissolution.
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Select Batch
Purity:99.25%
Contact us for more batch information
All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | Cronidipine (LF 20254), a calcium channel antagonist, is used potentially for the treatment of hypertension and myocardia ischemia. |
| In vivo | In acute experiments, Cronidipine was shown to be more potent than nifedipine and nicardipine in reducing blood pressure after i.v. and oral administration with less tachycardia. The hypotensive effects of Cronidipine (10 mg/kg) lasted for greater than 24 h, whereas the blood pressure-lowering effects of nifedipine and nicardipine (10 mg/kg) disappeared after 6 h. Cronidipinegiven orally once a day at 10 mg/kg for 14 days to spontaneously hypertensive rats, led to a marked and persistent decrease in blood pressure, with no significant changes in heart rate. In an attempt to prevent the development of hypertension, Cronidipine (3 and 10 mg/kg) was given once a day for 8 weeks to 5-week-old SHR. On the last day of treatment, Cronidipine had markedly reduced blood pressure over a 24 h period, however, there was no reduction of left ventricular hypertrophy, since body weight and left ventricular weight was not significantly different between control and treated groups.[2] |
| Alias | LF-20254, LF20254, LF 20254, LF 2.0254 |
| Molecular Weight | 598.04 |
| Formula | C30H32ClN3O8 |
| Cas No. | 113759-50-5 |
| Smiles | C(OCC1OC2(OC1)CCN(CC2)C3=CC=C(Cl)C=C3)(=O)C=4C(C(C(OC)=O)=C(C)NC4C)C5=CC(N(=O)=O)=CC=C5 |
| Relative Density. | 1.31g/cm3 |
Storage & Solubility Information
| Storage | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice. | ||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 55 mg/mL (91.97 mM), Sonication is recommended.  | ||||||||||||||||||||||||||||||
Solution Preparation Table | |||||||||||||||||||||||||||||||
DMSO
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Calculator
In Vivo Formulation Calculator (Clear solution)
Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
For example, your dosage is 10 mg/kg Each animal weighs 20 g, and the dosage volume is 100 μL . A total of 10 animals were administered, and the formula you used is 5% 
DMSO+30% PEG300+5% Tween 80+60% ddH2O. So your working solution concentration is 2 mg/mL。Mother liquor preparation method: 2 mg of drug dissolved in 50 μL DMSO (mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.
(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
Dose Conversion
You can also refer to dose conversion for different animals. More Dose Conversion
References
1.Pruneau D, et al. Cardiovascular properties of LF 2.0254, a new potent vasoselective calcium channel blocker with a slow onset of action. Fundam Clin Pharmacol. 1990;4(2):223-243.2.Pruneau D, et al. Antihypertensive activity of a new calcium channel blocker LF 2.0254, in spontaneously hypertensive rats: a comparison with nifedipine and nicardipine. Arch Int Pharmacodyn Ther. 1988;295:109-124.3.Baillet G, et al. Radio high-performance liquid chromatographic determination of 14C-labelled LF 2-0254, A 1,4-dihydropyridine calcium antagonist, in rat and dog plasma using off-line liquid scintillation counting. J Chromatogr. 1988;456(1):183-190.
Tech Support
Please see Inhibitor Handling Instructions for more frequently ask questions. Topics include: how to prepare stock solutions, how to store products, and cautions on cell-based assays & animal experiments, etc
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