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CUR5g
🥰Excellent
Catalog No. T73550Cas No. 1370032-20-4
Alias CUR-5g
CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
CUR5g
🥰Excellent
Purity: 98.92%
Catalog No. T73550Alias CUR-5gCas No. 1370032-20-4
CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer.
| Pack Size | Price | Availability | Quantity |
|---|---|---|---|
| 1 mg | $93 | In Stock | |
| 5 mg | $228 | In Stock | |
| 10 mg | $363 | In Stock | |
| 25 mg | $728 | In Stock | |
| 50 mg | $1,160 | In Stock | |
| 100 mg | $1,730 | In Stock | |
| 1 mL x 10 mM (in DMSO) | $253 | In Stock |
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Purity:98.92%
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All TargetMol products are for research purposes only and cannot be used for human consumption. We do not provide products or services to individuals. Please comply with the intended use and do not use TargetMol products for any other purpose.Product Introduction
Bioactivity
Chemical Properties
| Description | CUR5g is an autophagy inhibitor that inhibits migration and colony formation in A549 cells and acts through a UVRAG-dependent mechanism by blocking the recruitment of STX17 to autophagosomes.CUR5g is often used in combination with cisplatin for the study of cancer. |
| In vitro | In A549 cells, CUR5g (at concentrations of 0, 1, 5, 10, 20, and 40 μM; observed at 3, 6, 12, and 24 hours) induces extensive cytoplasmic vacuolization, and the GFP-LC3B signal shifts from diffuse cytosolic staining to a punctate pattern outlining autophagosomes[1]. |
| In vivo | CUR5g (40 mg/kg) and cisplatin (1 mg/kg), administered via the caudal vein every other day for a total of 15 days, were able to retard the growth of xenografted tumors. The combined treatment of CUR5g and cisplatin nearly completely inhibited tumor growth[1]. |
| Alias | CUR-5g |
| Molecular Weight | 344.41 |
| Formula | C22H20N2O2 |
| Cas No. | 1370032-20-4 |
| Smiles | C(\C=1C=2C(NC1)=CC=CC2)=C\3/C(=O)\C(=C\C4=CC=C(O)C=C4)\CN(C)C3 |
Storage & Solubility Information
| Storage | store at low temperature | store at -20°C | Shipping with blue ice. | |||||||||||||||||||||||||||||||||||
| Solubility Information | DMSO: 40 mg/mL (116.14 mM), Sonication is recommended. | |||||||||||||||||||||||||||||||||||
Solution Preparation Table | ||||||||||||||||||||||||||||||||||||
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Please enter your animal experiment information in the following box and click Calculate to obtain the mother liquor preparation method and in vivo formula preparation method:
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(mother liquor concentration of 40 mg/mL), if you need to configure a concentration that exceeds the solubility of the product, please contact us first.Preparation method for in vivo formula: Take 50 μL DMSO main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarify
main solution, add 300 μLPEG300 mix well and clarify, then add 50 more μL Tween 80, mix well and clarify, then add 600 more μLddH2O mix well and clarifyFor Reference Only. Please develop an appropriate dissolution method based on your laboratory animals and route of administration.
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